1500. Gastric Carcinoma Survival Related with Helicobacter pylori Infection in Cali, Colombia: A Hospital-Based Cancer Study

BACKGROUND: Gastric carcinoma (GC) has been associated with the presence of Helicobacter pylori infection. The infection rates vary according to geographic region and the majority of infected persons remain asymptomatic. Recent studies have suggested a controversial role of H. pylori infection in GC...

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Autores principales: Rosso, Fernando, Carlos Bravo, Juan, Parra-Lara, Luis Gabriel, Camilo Falla, Juan, Eduardo Bravo, Luis, Zambrano, Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6809176/
http://dx.doi.org/10.1093/ofid/ofz360.1364
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author Rosso, Fernando
Carlos Bravo, Juan
Parra-Lara, Luis Gabriel
Camilo Falla, Juan
Eduardo Bravo, Luis
Zambrano, Angela
author_facet Rosso, Fernando
Carlos Bravo, Juan
Parra-Lara, Luis Gabriel
Camilo Falla, Juan
Eduardo Bravo, Luis
Zambrano, Angela
author_sort Rosso, Fernando
collection PubMed
description BACKGROUND: Gastric carcinoma (GC) has been associated with the presence of Helicobacter pylori infection. The infection rates vary according to geographic region and the majority of infected persons remain asymptomatic. Recent studies have suggested a controversial role of H. pylori infection in GC prognosis. The GC incidence rate in Colombia is among the highest of all Latin-American countries at 18.5 per 100,000 people. Furthermore, GC is responsible for the highest mortality rate among all malignancies in the country. This study aimed to describe GC survival in patients with H. pylori infection. METHODS: Hospital registries for all patients diagnosed with GC between 2000 and 2015 were consulted for clinical data. The hospital-based cancer registry was cross-linked with a population-based cancer registry to obtain IARC/WHO ICD-O-3 classification and follow-up information on all patients. Survival analysis was estimated using the Kaplan–Meier method. Differences between H. pylori cases and non-H. pylori cases were assessed through Pearson chi-2, Fisher exact test, log-rank test, and Cox regression. RESULTS: A total of 500 GC cases were included and 8.6% had H. pylori infection. In the H. pylori cases, the median age was 62 years (IQR = 52–71), 56% were men. All cases had a tumor size >5 mm, Lauren classification was 60% intestinal type and 40% diffuse type. Regarding clinical stage, 33% of the patients were classified as localized (TNM AJCC 7th edition: IA, IB, IIA), 35% as regional (IIB, IIIA, IIIB, IIIC) and 12% were distant (IV). There was a statistically significant difference between H. pylori cases and non-H. pylori cases survival (P = 0.0151). In univariate analysis, H. pylori infection was associated with better cancer-specific survival [HR = 0.5398; 95% CI: 0.3255–0.8950; P = 0.017]. In multivariate analysis, H. pylori infection [HR = 0.5934; 95% CI: 0.3577–0.9843; P = 0.043] and clinical stage [HR = 1.5327; 95% CI: 1.3672–1.7182; P < 0.001] were independent prognostic factors for cancer-specific. CONCLUSION: This study showed that H. pylori infection is a beneficial prognostic indicator in patients with GC Cases, and GC survival in cases with H. pylori infection was better compared with non-H. pylori cases. [Image: see text] DISCLOSURES: All authors: No reported disclosures.
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spelling pubmed-68091762019-10-28 1500. Gastric Carcinoma Survival Related with Helicobacter pylori Infection in Cali, Colombia: A Hospital-Based Cancer Study Rosso, Fernando Carlos Bravo, Juan Parra-Lara, Luis Gabriel Camilo Falla, Juan Eduardo Bravo, Luis Zambrano, Angela Open Forum Infect Dis Abstracts BACKGROUND: Gastric carcinoma (GC) has been associated with the presence of Helicobacter pylori infection. The infection rates vary according to geographic region and the majority of infected persons remain asymptomatic. Recent studies have suggested a controversial role of H. pylori infection in GC prognosis. The GC incidence rate in Colombia is among the highest of all Latin-American countries at 18.5 per 100,000 people. Furthermore, GC is responsible for the highest mortality rate among all malignancies in the country. This study aimed to describe GC survival in patients with H. pylori infection. METHODS: Hospital registries for all patients diagnosed with GC between 2000 and 2015 were consulted for clinical data. The hospital-based cancer registry was cross-linked with a population-based cancer registry to obtain IARC/WHO ICD-O-3 classification and follow-up information on all patients. Survival analysis was estimated using the Kaplan–Meier method. Differences between H. pylori cases and non-H. pylori cases were assessed through Pearson chi-2, Fisher exact test, log-rank test, and Cox regression. RESULTS: A total of 500 GC cases were included and 8.6% had H. pylori infection. In the H. pylori cases, the median age was 62 years (IQR = 52–71), 56% were men. All cases had a tumor size >5 mm, Lauren classification was 60% intestinal type and 40% diffuse type. Regarding clinical stage, 33% of the patients were classified as localized (TNM AJCC 7th edition: IA, IB, IIA), 35% as regional (IIB, IIIA, IIIB, IIIC) and 12% were distant (IV). There was a statistically significant difference between H. pylori cases and non-H. pylori cases survival (P = 0.0151). In univariate analysis, H. pylori infection was associated with better cancer-specific survival [HR = 0.5398; 95% CI: 0.3255–0.8950; P = 0.017]. In multivariate analysis, H. pylori infection [HR = 0.5934; 95% CI: 0.3577–0.9843; P = 0.043] and clinical stage [HR = 1.5327; 95% CI: 1.3672–1.7182; P < 0.001] were independent prognostic factors for cancer-specific. CONCLUSION: This study showed that H. pylori infection is a beneficial prognostic indicator in patients with GC Cases, and GC survival in cases with H. pylori infection was better compared with non-H. pylori cases. [Image: see text] DISCLOSURES: All authors: No reported disclosures. Oxford University Press 2019-10-23 /pmc/articles/PMC6809176/ http://dx.doi.org/10.1093/ofid/ofz360.1364 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Abstracts
Rosso, Fernando
Carlos Bravo, Juan
Parra-Lara, Luis Gabriel
Camilo Falla, Juan
Eduardo Bravo, Luis
Zambrano, Angela
1500. Gastric Carcinoma Survival Related with Helicobacter pylori Infection in Cali, Colombia: A Hospital-Based Cancer Study
title 1500. Gastric Carcinoma Survival Related with Helicobacter pylori Infection in Cali, Colombia: A Hospital-Based Cancer Study
title_full 1500. Gastric Carcinoma Survival Related with Helicobacter pylori Infection in Cali, Colombia: A Hospital-Based Cancer Study
title_fullStr 1500. Gastric Carcinoma Survival Related with Helicobacter pylori Infection in Cali, Colombia: A Hospital-Based Cancer Study
title_full_unstemmed 1500. Gastric Carcinoma Survival Related with Helicobacter pylori Infection in Cali, Colombia: A Hospital-Based Cancer Study
title_short 1500. Gastric Carcinoma Survival Related with Helicobacter pylori Infection in Cali, Colombia: A Hospital-Based Cancer Study
title_sort 1500. gastric carcinoma survival related with helicobacter pylori infection in cali, colombia: a hospital-based cancer study
topic Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6809176/
http://dx.doi.org/10.1093/ofid/ofz360.1364
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