1165. Risk Factors for Bloodstream Infections During Extracorporeal Membrane Oxygenation (ECMO)

BACKGROUND: Although bloodstream infections (BSIs) are important complications of ECMO, data on clinical characteristics of ECMO-associated BSIs remain limited. This study aimed to investigate clinical characteristics of ECMO-associated BSIs and evaluate the role of routine active surveillance cultures (ASCs) in predicting subsequent BSIs. METHODS: We reviewed the medical records of adult patients who received ECMO for >48 hours in 2 teaching hospitals between January 2013 and March 2019. ECMO-associated BSIs were defined as bacteremia occurring from 48 hours after ECMO initiation. ASCs for multidrug-resistant organisms were obtained from nasal, axillary, inguinal, and rectal swabs when patients were admitted to the ICUs. RESULTS: Overall, 28 of 110 (25.4%) patients had BSIs within the median 7 days after ECMO initiation. Table 1 shows the clinical characteristics of patients with ECMO-associated BSIs. Among BSI cases, the most common pathogens were Candida spp. (25%). Longer ECMO days (P < 0.01), steroid use (P = 0.02), and more blood transfusions (P < 0.01) were associated with BSIs. However, there was no association between the results of ASCs and subsequent pathogens of BSIs. CONCLUSION: BSIs during ECMO were associated with longer ECMO duration, steroid use and blood transfusion. The pathogens of BSIs could not be related to ASCs. [Image: see text] DISCLOSURES: All authors: No reported disclosures.