903. Resensitization to β-Lactams in Enterococci Depends on Penicillin-Binding Protein (PBP) Mislocalization and Is Mediated by a Single Protein That Modulates Cell Membrane (CM) Adaptation to Daptomycin (DAP)

BACKGROUND: DAP disrupts bacterial CM by binding to septal anionic phospholipids (APLs). LiaX, an effector of the LiaFSR stress system, modulates DAP-R by diverting APLs away from the septum. Enterococci are intrinsically resistant to β-lactams due to the presence of PBPs (e.g., PBP5) with low affin...

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Detalles Bibliográficos
Autores principales: Khan, Ayesha, Nguyen, April, Panesso, Diana, Vitrac, Heidi, Miller, William R, Tran, Truc T, Shamoo, Yousif, Arthur, Michel, Arias, Cesar A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6809366/
http://dx.doi.org/10.1093/ofid/ofz359.062

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