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1560. Pharmacokinetics–Pharmacodynamics (PK-PD) of Gepotidacin (GEP) Against Escherichia coli in Murine Pyelonephritis and Thigh Infection Models

BACKGROUND: GEP, a first in class novel triazaacenaphthylene bacterial topoisomerase inhibitor, inhibits bacterial replication and has in vitro activity against key pathogens implicated in a range of infections, including drug-resistant strains of E. coli associated with acute cystitis. METHODS: PK...

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Detalles Bibliográficos
Autores principales:	Barth, Aline, Mininger, Cindy l, Lewandowski, Thomas, Hossain, Mohammad, Rittenhouse, Stephen, Hoover, Jennifer
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Abstracts
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6809414/ http://dx.doi.org/10.1093/ofid/ofz360.1424

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