2306. Impact of Cytomegalovirus Disease on New-Onset Dementia: Population-Based-Matched Case–Control Cohort Study

BACKGROUND: The association of human cytomegalovirus (CMV) with dementia is still controversial. Previous studies suggested that serostatus of latent CMV infection assessed by serum CMV IgG could play a role in development of neurodegeneration with cognitive impairment. This study is aimed to evaluate the relation of CMV tissue invasive diseases to vascular dementia and Alzheimer’s dementia. METHODS: The ICD-10 codes from the National Health Insurance Database covering 50 million people were used to collect the patient group (n = 687) aged ≥ 40 years with CMV tissue invasive end-organ diseases and control group (n = 3,435) matched by non-CMV infection, age and sex with 1:5 ratio. The subjects were retrieved for enrolled patients during 2010–2014 with wash-out period for 6 years, and followed until December 2016. RESULTS: Multivariate regression model adjusted by age and sex showed a significantly higher incidence rate of dementia (odds ratio [OR], 2.10 and 95% confidence intervals [CI], 1.45–3.05) in patients with CMV disease. According to the type of dementia, the risk of vascular dementia in patient group (OR, 3.31 and 95% CI, 1.30–8.41) was higher than Alzheimer’s dementia (OR, 1.74 and 95% CI, 1.09–2.78). In the age subgroup analysis adjusted by sex, patients aged 40–59 years with CMV disease had a higher risk of dementia than those aged ≥ 60 years (OR, 12.3 [95% CI, 3.2–47.6] vs. 1.8 [95% CI, 1.2–2.7], P = 0.010). CONCLUSION: CMV disease independently increased the risk of vascular dementia as well as Alzheimer’s dementia. [Image: see text] [Image: see text] [Image: see text] [Image: see text] DISCLOSURES: All authors: No reported disclosures.