158. Invasive Group B Streptococcal Diseases in Adults: A Retrospective Study in Thailand (2013–2017)

BACKGROUND: Group B Streptococcus (GBS) has been increasingly associated with invasive diseases in nonpregnant adults. This study aims to describe the epidemiology of invasive GBS (iGBS) diseases in adult patients. METHODS: A retrospective cohort study was conducted at Siriraj Hospital between January 1, 2013 and December 31, 2017. We included adult patients with a positive culture of GBS isolated from sterile sites. RESULTS: Among 224 patients recruited to the study, 170 patients (75.9%) had bacteremia. The median age of all patients was 63 years (IQR 53–73 years) and 52.7% were female. Approximately 80% of all patients had comorbid diseases. Diabetes mellitus (38.8%), cancer (18.8%) and heart disease (12.5%) were the three most common comorbidities. Skin and soft-tissue infection (30.8%), septic arthritis (21.4%), primary bacteremia (21%), and meningitis (7.1%) were the four most common presenting syndrome of iGBS diseases. Overall mortality within 30 days of infection was 12%. Non-survived patients were older, had chronic kidney disease, bacteremia, pneumonia and had at least one comorbidity than survived patients. However, only pneumonia was found independently associated with the 30-day overall mortality, with adjusted odd ratio (aOR) of 24.96 (95% confidence interval [CI]: 5.95–104.75). Antimicrobial susceptibility testing of 69 isolates demonstrated that 7 (10%) and 9 (13%) were resistant to erythromycin and clindamycin, respectively. All isolates remain susceptible to penicillin. CONCLUSION: Invasive GBS is an emerging disease in non-pregnant adults particularly in elderly and diabetes mellitus patients. Two-thirds of iGBS patients have concomittant bacteremia. Even though the overall mortality was 12% but a significant morbidity was observed. DISCLOSURES: All authors: No reported disclosures.