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1568. The Pharmacodynamic–Toxicodynamic Relationship of AUC and CMAX in Vancomycin-Induced Kidney Injury
BACKGROUND: Vancomycin induces exposure-related acute kidney injury [AKI]; yet the toxicodynamic (TD) driver for toxicity (area under the curve [AUC], vs. maximum concentration [CMAX] vs. trough concentrations [CMIN]) remains unclear. Recent vancomycin guidelines now recommend monitoring AUC over tr...
Autores principales: | Avedissian, Sean N, Pais, Gwendolyn M, Liu, Jiajun, O’Donnell, J Nicholas, Lodise, Thomas, Prozialeck, Walter, Lamar, Peter, Neely, Michael, Scheetz, Marc H |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6809992/ http://dx.doi.org/10.1093/ofid/ofz360.1432 |
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