1536. Population Pharmacokinetic Analysis of Baloxavir Morboxil, a Cap-Dependent Endonuclease Inhibitor, in Adult and Adolescent Healthy Subjects and Influenza Patients and Exposure-Response Relationships in the Patients at High-Risk of Influenza Complications

BACKGROUND: Baloxavir marboxil is a prodrug of baloxavir acid which is a selective inhibitor of cap-dependent endonuclease. The global Phase 3 study conducted in the influenza patients at high-risk of influenza complications (CAPSTONE-2) enrolled adult and adolescent patients from 2016 to 2018. Balo...

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Detalles Bibliográficos
Autores principales: Koshimichi, Hiroki, Retout, Sylvie, Cosson, Valérie F, De Buck, Stefan, Tsuda, Yoshiyuki, Ishibashi, Toru, Wajima, Toshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6810044/
http://dx.doi.org/10.1093/ofid/ofz360.1400

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