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2314. Burden of Respiratory Syncytial Virus (RSV) Infection Among Hospitalized Older Adults and Those with Underlying Chronic Obstructive Pulmonary Disease (COPD) or Congestive Heart Failure (CHF)
BACKGROUND: Data are limited about the burden of respiratory syncytial virus (RSV)-related hospitalizations in older adults and those with COPD or CHF. METHODS: We conducted prospective surveillance at two hospitals from October 2018 to March 2019 for adults ≥50 years of age admitted with acute resp...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6810302/ http://dx.doi.org/10.1093/ofid/ofz360.1992 |
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author | Anderson, Evan J Hussaini, Laila Bristow, Laurel Tippett, Ashley Gibson, Theda Hart, Mari Salazar, Luis Gaffney, Michelle Benyeogor, Ifeyinwa Kanayo Cheng, Andrew Drobeniuc, Ana Traenkner, Jessica Fayad, Danielle Washington, Wesley Emerson, Lisa Schwartz, Natalia Greaves, Kandra Todd, Sean Stanley, Corshé Bechnak, Amer Chaaya, Rody Bou Al-Husien, Zayna Deović, Rijalda Winston, Juton Ahmed, Dilshad Rafi Li, Wensheng Le, Khuong Singh, Aditya Spencer, Jennifer E Muchinsky, Amy Zaks, Kathryn Nesheim, Wendy Stephens, Kathy Swerdlow, David L Hubler, Robin Agosti, Yasmeen Munye, Mohamed Jadhao, Samadhan Ha, Binh McCracken, Courtney Kraft, Colleen Rostad, Christina A Kao, Carol Lopman, Ben Yildirim, Inci Anderson, Larry Rouphael, Nadine Rouphael, Nadine |
author_facet | Anderson, Evan J Hussaini, Laila Bristow, Laurel Tippett, Ashley Gibson, Theda Hart, Mari Salazar, Luis Gaffney, Michelle Benyeogor, Ifeyinwa Kanayo Cheng, Andrew Drobeniuc, Ana Traenkner, Jessica Fayad, Danielle Washington, Wesley Emerson, Lisa Schwartz, Natalia Greaves, Kandra Todd, Sean Stanley, Corshé Bechnak, Amer Chaaya, Rody Bou Al-Husien, Zayna Deović, Rijalda Winston, Juton Ahmed, Dilshad Rafi Li, Wensheng Le, Khuong Singh, Aditya Spencer, Jennifer E Muchinsky, Amy Zaks, Kathryn Nesheim, Wendy Stephens, Kathy Swerdlow, David L Hubler, Robin Agosti, Yasmeen Munye, Mohamed Jadhao, Samadhan Ha, Binh McCracken, Courtney Kraft, Colleen Rostad, Christina A Kao, Carol Lopman, Ben Yildirim, Inci Anderson, Larry Rouphael, Nadine Rouphael, Nadine |
author_sort | Anderson, Evan J |
collection | PubMed |
description | BACKGROUND: Data are limited about the burden of respiratory syncytial virus (RSV)-related hospitalizations in older adults and those with COPD or CHF. METHODS: We conducted prospective surveillance at two hospitals from October 2018 to March 2019 for adults ≥50 years of age admitted with acute respiratory infections (ARI) and adults of any age with COPD or CHF-related admissions. Adults were eligible if they were residents of an 8 county region in Atlanta, Georgia. Asymptomatic adults ≥50 years of age were enrolled as controls. Nasopharyngeal and oropharyngeal swabs were tested for RSV and influenza (Flu) using BioFire® FilmArray® Respiratory Viral Panel (RVP) and acute/convalescent serology was obtained for RSV antibodies detection by enzyme immunoassay against RSV lysate. Standard of care results were included for enrollees. We compare the number of RSV+, Flu+ and RSV−/Flu− cases along with demographic features and outcomes. RESULTS: We screened 12,453 patients to identify 1,515 eligible adults of which 617 (41%) were enrolled. The most common reasons for failing to enroll were refusal (676, 75%) and inability to obtain informed consent (221, 25%). Of the 617, 36 (6%) were RSV+ and 41 (7%) were Flu+. RSV was detected in 1/126 (0.8%) and Flu in 0/126 healthy controls. RSV+ occurred earlier in surveillance and peaked at a higher frequency (figure). Clinical characteristics and outcomes are in the table. In a convenience sample, a four-fold rise in RSV antibody titer was detected among 8/15 RSV+, 0/42 RSV−/Flu−, and 0/42 healthy controls. CONCLUSION: The burden and outcomes for RSV are similar to Flu in adults admitted to the hospital with ARI, CHF, or COPD. A vaccine for RSV would be beneficial. [Image: see text] [Image: see text] DISCLOSURES: Nadine Rouphael, MD, Merck: I conduct as Emory PI the PNEUMO MERCK study at Emory, Research Grant; Pfizer: I conduct as co-PI the RSV PFIZER study at Emory, Research Grant; Sanofi-Pasteur: I conducted as Emory PI the CDIFFENSE trial at Emory, Research Grant. |
format | Online Article Text |
id | pubmed-6810302 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-68103022019-10-28 2314. Burden of Respiratory Syncytial Virus (RSV) Infection Among Hospitalized Older Adults and Those with Underlying Chronic Obstructive Pulmonary Disease (COPD) or Congestive Heart Failure (CHF) Anderson, Evan J Hussaini, Laila Bristow, Laurel Tippett, Ashley Gibson, Theda Hart, Mari Salazar, Luis Gaffney, Michelle Benyeogor, Ifeyinwa Kanayo Cheng, Andrew Drobeniuc, Ana Traenkner, Jessica Fayad, Danielle Washington, Wesley Emerson, Lisa Schwartz, Natalia Greaves, Kandra Todd, Sean Stanley, Corshé Bechnak, Amer Chaaya, Rody Bou Al-Husien, Zayna Deović, Rijalda Winston, Juton Ahmed, Dilshad Rafi Li, Wensheng Le, Khuong Singh, Aditya Spencer, Jennifer E Muchinsky, Amy Zaks, Kathryn Nesheim, Wendy Stephens, Kathy Swerdlow, David L Hubler, Robin Agosti, Yasmeen Munye, Mohamed Jadhao, Samadhan Ha, Binh McCracken, Courtney Kraft, Colleen Rostad, Christina A Kao, Carol Lopman, Ben Yildirim, Inci Anderson, Larry Rouphael, Nadine Rouphael, Nadine Open Forum Infect Dis Abstracts BACKGROUND: Data are limited about the burden of respiratory syncytial virus (RSV)-related hospitalizations in older adults and those with COPD or CHF. METHODS: We conducted prospective surveillance at two hospitals from October 2018 to March 2019 for adults ≥50 years of age admitted with acute respiratory infections (ARI) and adults of any age with COPD or CHF-related admissions. Adults were eligible if they were residents of an 8 county region in Atlanta, Georgia. Asymptomatic adults ≥50 years of age were enrolled as controls. Nasopharyngeal and oropharyngeal swabs were tested for RSV and influenza (Flu) using BioFire® FilmArray® Respiratory Viral Panel (RVP) and acute/convalescent serology was obtained for RSV antibodies detection by enzyme immunoassay against RSV lysate. Standard of care results were included for enrollees. We compare the number of RSV+, Flu+ and RSV−/Flu− cases along with demographic features and outcomes. RESULTS: We screened 12,453 patients to identify 1,515 eligible adults of which 617 (41%) were enrolled. The most common reasons for failing to enroll were refusal (676, 75%) and inability to obtain informed consent (221, 25%). Of the 617, 36 (6%) were RSV+ and 41 (7%) were Flu+. RSV was detected in 1/126 (0.8%) and Flu in 0/126 healthy controls. RSV+ occurred earlier in surveillance and peaked at a higher frequency (figure). Clinical characteristics and outcomes are in the table. In a convenience sample, a four-fold rise in RSV antibody titer was detected among 8/15 RSV+, 0/42 RSV−/Flu−, and 0/42 healthy controls. CONCLUSION: The burden and outcomes for RSV are similar to Flu in adults admitted to the hospital with ARI, CHF, or COPD. A vaccine for RSV would be beneficial. [Image: see text] [Image: see text] DISCLOSURES: Nadine Rouphael, MD, Merck: I conduct as Emory PI the PNEUMO MERCK study at Emory, Research Grant; Pfizer: I conduct as co-PI the RSV PFIZER study at Emory, Research Grant; Sanofi-Pasteur: I conducted as Emory PI the CDIFFENSE trial at Emory, Research Grant. Oxford University Press 2019-10-23 /pmc/articles/PMC6810302/ http://dx.doi.org/10.1093/ofid/ofz360.1992 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Abstracts Anderson, Evan J Hussaini, Laila Bristow, Laurel Tippett, Ashley Gibson, Theda Hart, Mari Salazar, Luis Gaffney, Michelle Benyeogor, Ifeyinwa Kanayo Cheng, Andrew Drobeniuc, Ana Traenkner, Jessica Fayad, Danielle Washington, Wesley Emerson, Lisa Schwartz, Natalia Greaves, Kandra Todd, Sean Stanley, Corshé Bechnak, Amer Chaaya, Rody Bou Al-Husien, Zayna Deović, Rijalda Winston, Juton Ahmed, Dilshad Rafi Li, Wensheng Le, Khuong Singh, Aditya Spencer, Jennifer E Muchinsky, Amy Zaks, Kathryn Nesheim, Wendy Stephens, Kathy Swerdlow, David L Hubler, Robin Agosti, Yasmeen Munye, Mohamed Jadhao, Samadhan Ha, Binh McCracken, Courtney Kraft, Colleen Rostad, Christina A Kao, Carol Lopman, Ben Yildirim, Inci Anderson, Larry Rouphael, Nadine Rouphael, Nadine 2314. Burden of Respiratory Syncytial Virus (RSV) Infection Among Hospitalized Older Adults and Those with Underlying Chronic Obstructive Pulmonary Disease (COPD) or Congestive Heart Failure (CHF) |
title | 2314. Burden of Respiratory Syncytial Virus (RSV) Infection Among Hospitalized Older Adults and Those with Underlying Chronic Obstructive Pulmonary Disease (COPD) or Congestive Heart Failure (CHF) |
title_full | 2314. Burden of Respiratory Syncytial Virus (RSV) Infection Among Hospitalized Older Adults and Those with Underlying Chronic Obstructive Pulmonary Disease (COPD) or Congestive Heart Failure (CHF) |
title_fullStr | 2314. Burden of Respiratory Syncytial Virus (RSV) Infection Among Hospitalized Older Adults and Those with Underlying Chronic Obstructive Pulmonary Disease (COPD) or Congestive Heart Failure (CHF) |
title_full_unstemmed | 2314. Burden of Respiratory Syncytial Virus (RSV) Infection Among Hospitalized Older Adults and Those with Underlying Chronic Obstructive Pulmonary Disease (COPD) or Congestive Heart Failure (CHF) |
title_short | 2314. Burden of Respiratory Syncytial Virus (RSV) Infection Among Hospitalized Older Adults and Those with Underlying Chronic Obstructive Pulmonary Disease (COPD) or Congestive Heart Failure (CHF) |
title_sort | 2314. burden of respiratory syncytial virus (rsv) infection among hospitalized older adults and those with underlying chronic obstructive pulmonary disease (copd) or congestive heart failure (chf) |
topic | Abstracts |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6810302/ http://dx.doi.org/10.1093/ofid/ofz360.1992 |
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