BRK phosphorylates SMAD4 for proteasomal degradation and inhibits tumor suppressor FRK to control SNAIL, SLUG, and metastatic potential

The tumor-suppressing function of SMAD4 is frequently subverted during mammary tumorigenesis, leading to cancer growth, invasion, and metastasis. A long-standing concept is that SMAD4 is not regulated by phosphorylation but ubiquitination. Our search for signaling pathways regulated by breast tumor...

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Detalles Bibliográficos
Autores principales: Miah, S., Banks, C. A. S., Ogunbolude, Y., Bagu, E. T., Berg, J. M., Saraf, A., Tettey, T. T., Hattem, G., Dayebgadoh, G., Kempf, C. G., Sardiu, M., Napper, S., Florens, L., Lukong, K. E., Washburn, M. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6810434/
https://www.ncbi.nlm.nih.gov/pubmed/31681835
http://dx.doi.org/10.1126/sciadv.aaw3113

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