Cargando…

2772. HCMV gB Ectodomain Subunit and gB mRNA Vaccines Reduce AD-3 Immunodominance and Elicit More Durable Antibody Responses Than gB/MF59 Immunization

BACKGROUND: A vaccine to prevent maternal acquisition of human cytomegalovirus (HCMV) during pregnancy is one potential strategy to reduce the incidence of congenital disease. The MF59-adjuvanted glycoprotein B (gB/MF59) protein subunit vaccine is the most efficacious tested to-date, though achieved...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nelson, Cody S, Jenks, Jennifer A, Pardi, Norbert, Roark, Hunter K, Goodwin, Matthew, Weissman, Drew, Permar, Sallie R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Abstracts
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6810577/ http://dx.doi.org/10.1093/ofid/ofz360.2449

Ejemplares similares

2651. Protection Against Human Cytomegalovirus Acquisition Is Associated with IgG Binding to Cell-Associated CMV glycoprotein B in Two Historical gB/MF59 Vaccine Cohorts
por: Jenks, Jennifer A, et al.
Publicado: (2019)

Complement enhances in vitro neutralizing potency of antibodies to human cytomegalovirus glycoprotein B (gB) and immune sera induced by gB/MF59 vaccination
por: Li, Fengsheng, et al.
Publicado: (2017)

Seronegative patients vaccinated with cytomegalovirus gB-MF59 vaccine have evidence of neutralising antibody responses against gB early post-transplantation
por: Baraniak, Ilona, et al.
Publicado: (2019)

Modulation of Epstein-Barr Virus Glycoprotein B (gB) Fusion Activity by the gB Cytoplasmic Tail Domain
por: Garcia, Nicholas J., et al.
Publicado: (2013)

Positively Selected Sites at HCMV gB Furin Processing Region and Their Effects in Cleavage Efficiency
por: Stangherlin, Lucas M., et al.
Publicado: (2017)

The cytomegalovirus gB/MF59 vaccine candidate induces antibodies against an antigenic domain controlling cell-to-cell spread
por: Gomes, A. C., et al.
Publicado: (2023)

Functional Fluorescent Protein Insertions in Herpes Simplex Virus gB Report on gB Conformation before and after Execution of Membrane Fusion
por: Gallagher, John R., et al.
Publicado: (2014)

A Native Human Monoclonal Antibody Targeting HCMV gB (AD-2 Site I)
por: McVoy, Michael M., et al.
Publicado: (2018)

Herpesvirus gB: A Finely Tuned Fusion Machine
por: Cooper, Rebecca S., et al.
Publicado: (2015)

Little role of anti-gB antibodies in neutralizing activity of patient's sera with human cytomegalovirus (HCMV) infection.
por: Park, J. W., et al.
Publicado: (2000)

MVA-Vectored Pentameric Complex (PC) and gB Vaccines Improve Pregnancy Outcome after Guinea Pig CMV Challenge, but Only gB Vaccine Reduces Vertical Transmission
por: Contreras, Heidi, et al.
Publicado: (2019)

Influence of N-glycosylation on Expression and Function of Pseudorabies Virus Glycoprotein gB
por: Vallbracht, Melina, et al.
Publicado: (2021)

Rationally designed Human Cytomegalovirus gB nanoparticle vaccine with improved immunogenicity
por: Perotti, Michela, et al.
Publicado: (2020)

UV-B promotes flavonoid biosynthesis in Ginkgo biloba by inducing the GbHY5-GbMYB1-GbFLS module
por: Liu, Sian, et al.
Publicado: (2023)

1113 Safety and Efficacy of a Cytomegalovirus Glycoprotein B (gB) Vaccine in Adolescent Girls
por: Bernstein, David I., et al.
Publicado: (2014)

Upward social mobility seen through elizas's transformation in G.B. Shaw's pygmalion/
por: Rosales Figueroa Iliana
Publicado: (2004)

Human Cytomegalovirus gH/gL Forms a Stable Complex with the Fusion Protein gB in Virions
por: Vanarsdall, Adam L., et al.
Publicado: (2016)

Antibody Titers Against Human Cytomegalovirus gM/gN and gB Among Pregnant Women and Their Infants
por: Talavera-Barber, Maria, et al.
Publicado: (2022)

Structural basis for membrane anchoring and fusion regulation of the Herpes Simplex Virus fusogen gB
por: Cooper, Rebecca S., et al.
Publicado: (2018)

Interaction Domain of Glycoproteins gB and gH of Marek's Disease Virus and Identification of an Antiviral Peptide with Dual Functions
por: Chi, Xiao-Jing, et al.
Publicado: (2013)

Computational repositioning of ethno medicine elucidated gB-gH-gL complex as novel anti herpes drug target
por: Basha, Syed Hussain, et al.
Publicado: (2013)

Cloning and sequencing gB, gD, and gM genes to perform the genetic variability of bovine herpesvirus-1 from Indonesia
por: Hidayati, Dewi Noor, et al.
Publicado: (2018)

Development of a Dual Fluorescent Microsphere Immunological Assay for Detection of Pseudorabies Virus gE and gB IgG Antibodies
por: Ji, Chihai, et al.
Publicado: (2020)

Human Cytomegalovirus (HCMV) Glycoprotein gB Promotes Virus Entry In Trans Acting as the Viral Fusion Protein Rather than as a Receptor-Binding Protein
por: Wille, Paul T., et al.
Publicado: (2013)

Repertoire characterization and validation of gB-specific human IgGs directly cloned from humanized mice vaccinated with dendritic cells and protected against HCMV
por: Theobald, Sebastian J., et al.
Publicado: (2020)

Measurement of Gluon Splitting Probability to Bottom Quark Pairs g_b\barb in Hadronic Z Decays
por: DELPHI Collaboration
Publicado: (2018)

Alphaherpesvirus gB Homologs Are Targeted to Extracellular Vesicles, but They Differentially Affect MHC Class II Molecules
por: Grabowska, Kinga, et al.
Publicado: (2020)

Optical Manipulation of Gb(3) Enriched Lipid Domains: Impact of Isomerization on Gb(3)‐Shiga Toxin B Interaction
por: Socrier, Larissa, et al.
Publicado: (2022)

Correction: Repertoire characterization and validation of gB-specific human IgGs directly cloned from humanized mice vaccinated with dendritic cells and protected against HCMV
por: Theobald, Sebastian J., et al.
Publicado: (2021)

Endogenous human cytomegalovirus gB is presented efficiently by MHC class II molecules to CD4(+) CTL
por: Hegde, Nagendra R., et al.
Publicado: (2005)

The Humoral Immune Response Against the gB Vaccine: Lessons Learnt from Protection in Solid Organ Transplantation
por: Gomes, Ariane C., et al.
Publicado: (2019)

A surface pocket in the cytoplasmic domain of the herpes simplex virus fusogen gB controls membrane fusion
por: Pataki, Zemplen, et al.
Publicado: (2022)

Protective anti-gB neutralizing antibodies targeting two vulnerable sites for EBV-cell membrane fusion
por: Zhang, Xiao, et al.
Publicado: (2022)

G-Protein β-Subunit Gene TaGB1-B Enhances Drought and Salt Resistance in Wheat
por: Xiong, Xin-Xin, et al.
Publicado: (2023)

Synthesis of Novel Peptide Dendrimers PDL-GB2 and PDL-G2
por: Yunzhu, Lin, et al.
Publicado: (2015)

Regulation of Herpes Simplex Virus gB-Induced Cell-Cell Fusion by Mutant Forms of gH/gL in the Absence of gD and Cellular Receptors
por: Atanasiu, Doina, et al.
Publicado: (2013)

Gesetzliche Neuregelung der „Kinderpornographie“ (§ 184b StGB)
por: Dreßing, Harald
Publicado: (2023)

Mapping sites of herpes simplex virus type 1 glycoprotein D that permit insertions and impact gD and gB receptors usage
por: Fan, Qing, et al.
Publicado: (2017)

Efficacy of a gB + gD-based subunit vaccine and the adjuvant granulocyte-macrophage colony stimulating factor for pseudorabies virus in rabbits
por: Cao, Zhi, et al.
Publicado: (2022)

The Membrane-Proximal Region (MPR) of Herpes Simplex Virus gB Regulates Association of the Fusion Loops with Lipid Membranes
por: Shelly, Spencer S., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_061u8426c745bn958r59246d0k