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1621. Acute Cardiovascular Events Among Adults Hospitalized with Influenza, FluSurv-NET, 2010–2018

BACKGROUND: Influenza virus infection most commonly causes acute respiratory tract illness, however may also lead to non-respiratory complications including acute cardiovascular (CV) events. We describe the frequency of and risk factors for acute CV events in adults hospitalized with influenza in th...

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Autores principales: Chow, Eric J, Rolfes, Melissa A, O’Halloran, Alissa, Anderson, Evan J, Bennett, Nancy M, Billing, Laurie M, Chai, Shua, Dufort, Elizabeth, Kim, Sue, Irizarry, Lourdes, Lynfield, Ruth, Monroe, Maya, Risk, Ilene, Stephens, Samantha, Talbot, Keipp, Thomas, Ann, Yousey-Hindes, Kim, Reed, Carrie, Garg, Shikha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6810601/
http://dx.doi.org/10.1093/ofid/ofz360.1485
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author Chow, Eric J
Rolfes, Melissa A
O’Halloran, Alissa
Anderson, Evan J
Bennett, Nancy M
Billing, Laurie M
Chai, Shua
Dufort, Elizabeth
Kim, Sue
Irizarry, Lourdes
Lynfield, Ruth
Monroe, Maya
Risk, Ilene
Stephens, Samantha
Talbot, Keipp
Thomas, Ann
Yousey-Hindes, Kim
Reed, Carrie
Garg, Shikha
author_facet Chow, Eric J
Rolfes, Melissa A
O’Halloran, Alissa
Anderson, Evan J
Bennett, Nancy M
Billing, Laurie M
Chai, Shua
Dufort, Elizabeth
Kim, Sue
Irizarry, Lourdes
Lynfield, Ruth
Monroe, Maya
Risk, Ilene
Stephens, Samantha
Talbot, Keipp
Thomas, Ann
Yousey-Hindes, Kim
Reed, Carrie
Garg, Shikha
author_sort Chow, Eric J
collection PubMed
description BACKGROUND: Influenza virus infection most commonly causes acute respiratory tract illness, however may also lead to non-respiratory complications including acute cardiovascular (CV) events. We describe the frequency of and risk factors for acute CV events in adults hospitalized with influenza in the United States. METHODS: We included adults aged > 18 years hospitalized during influenza seasons 2010–2011 through 2017–2018 in FluSurv-NET, a multi-state population-based surveillance system that includes detailed medical chart review of patients hospitalized with laboratory-confirmed influenza. We defined acute CV events by International Classification of Diseases (ICD) primary and secondary discharge diagnosis codes for acute heart failure (aHF), acute ischemic heart disease (aIHD), hypertensive crisis, cardiogenic shock, acute myocarditis, acute pericarditis and cardiac tamponade. We calculated the frequency of acute CV events and used multivariable logistic regression among the 87% treated with influenza antivirals to identify independent factors associated with aHF and aIHD, the two most common diagnoses. RESULTS: Of 80,374 adults hospitalized with laboratory-confirmed influenza, 12% had > 1 acute CV event. We found that aHF (46%) and aIHD (42%) were the most common, followed by hypertensive crisis (8%), cardiogenic shock (3%), acute myocarditis (0.7%), acute pericarditis (0.4%) and cardiac tamponade (0.2%). Compared with treated patients without an acute cardiovascular event, treated patients with aHF (Figure A) and aIHD (Figure B) were more likely to be older, currently/formerly use tobacco and have underlying conditions including cardiovascular disease, diabetes mellitus, and kidney disease. CONCLUSION: Among adults hospitalized with laboratory-confirmed influenza, acute CV events are common, particularly among those with prior cardiovascular disease. During the influenza season, clinicians should consider influenza virus infection in hospitalized adults who present with acute CV events. Non-respiratory complications, specifically aHF and aIHD, may be an under-recognized contributor to the burden of influenza. [Image: see text] [Image: see text] DISCLOSURES: All authors: No reported disclosures.
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spelling pubmed-68106012019-10-28 1621. Acute Cardiovascular Events Among Adults Hospitalized with Influenza, FluSurv-NET, 2010–2018 Chow, Eric J Rolfes, Melissa A O’Halloran, Alissa Anderson, Evan J Bennett, Nancy M Billing, Laurie M Chai, Shua Dufort, Elizabeth Kim, Sue Irizarry, Lourdes Lynfield, Ruth Monroe, Maya Risk, Ilene Stephens, Samantha Talbot, Keipp Thomas, Ann Yousey-Hindes, Kim Reed, Carrie Garg, Shikha Open Forum Infect Dis Abstracts BACKGROUND: Influenza virus infection most commonly causes acute respiratory tract illness, however may also lead to non-respiratory complications including acute cardiovascular (CV) events. We describe the frequency of and risk factors for acute CV events in adults hospitalized with influenza in the United States. METHODS: We included adults aged > 18 years hospitalized during influenza seasons 2010–2011 through 2017–2018 in FluSurv-NET, a multi-state population-based surveillance system that includes detailed medical chart review of patients hospitalized with laboratory-confirmed influenza. We defined acute CV events by International Classification of Diseases (ICD) primary and secondary discharge diagnosis codes for acute heart failure (aHF), acute ischemic heart disease (aIHD), hypertensive crisis, cardiogenic shock, acute myocarditis, acute pericarditis and cardiac tamponade. We calculated the frequency of acute CV events and used multivariable logistic regression among the 87% treated with influenza antivirals to identify independent factors associated with aHF and aIHD, the two most common diagnoses. RESULTS: Of 80,374 adults hospitalized with laboratory-confirmed influenza, 12% had > 1 acute CV event. We found that aHF (46%) and aIHD (42%) were the most common, followed by hypertensive crisis (8%), cardiogenic shock (3%), acute myocarditis (0.7%), acute pericarditis (0.4%) and cardiac tamponade (0.2%). Compared with treated patients without an acute cardiovascular event, treated patients with aHF (Figure A) and aIHD (Figure B) were more likely to be older, currently/formerly use tobacco and have underlying conditions including cardiovascular disease, diabetes mellitus, and kidney disease. CONCLUSION: Among adults hospitalized with laboratory-confirmed influenza, acute CV events are common, particularly among those with prior cardiovascular disease. During the influenza season, clinicians should consider influenza virus infection in hospitalized adults who present with acute CV events. Non-respiratory complications, specifically aHF and aIHD, may be an under-recognized contributor to the burden of influenza. [Image: see text] [Image: see text] DISCLOSURES: All authors: No reported disclosures. Oxford University Press 2019-10-23 /pmc/articles/PMC6810601/ http://dx.doi.org/10.1093/ofid/ofz360.1485 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Abstracts
Chow, Eric J
Rolfes, Melissa A
O’Halloran, Alissa
Anderson, Evan J
Bennett, Nancy M
Billing, Laurie M
Chai, Shua
Dufort, Elizabeth
Kim, Sue
Irizarry, Lourdes
Lynfield, Ruth
Monroe, Maya
Risk, Ilene
Stephens, Samantha
Talbot, Keipp
Thomas, Ann
Yousey-Hindes, Kim
Reed, Carrie
Garg, Shikha
1621. Acute Cardiovascular Events Among Adults Hospitalized with Influenza, FluSurv-NET, 2010–2018
title 1621. Acute Cardiovascular Events Among Adults Hospitalized with Influenza, FluSurv-NET, 2010–2018
title_full 1621. Acute Cardiovascular Events Among Adults Hospitalized with Influenza, FluSurv-NET, 2010–2018
title_fullStr 1621. Acute Cardiovascular Events Among Adults Hospitalized with Influenza, FluSurv-NET, 2010–2018
title_full_unstemmed 1621. Acute Cardiovascular Events Among Adults Hospitalized with Influenza, FluSurv-NET, 2010–2018
title_short 1621. Acute Cardiovascular Events Among Adults Hospitalized with Influenza, FluSurv-NET, 2010–2018
title_sort 1621. acute cardiovascular events among adults hospitalized with influenza, flusurv-net, 2010–2018
topic Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6810601/
http://dx.doi.org/10.1093/ofid/ofz360.1485
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