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219. Is the modified quick SOFA scale superior to quick SOFA in patients with diagnosed septic shock?

BACKGROUND: In this study it was aimed to compare the effects of qSOFA (Quick Sequential Organ Failure Assessment) score with modified qSOFA score (PLoS One. 2018 Sep 26;13(9):e0204608) for predicting one month survival in patients with diagnosed septic shock (SS) in a tertiary-care educational univ...

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Autores principales: Akyol, Deniz, Uyan Önal, Ayşe, Önal, Uğur, Akdağ, Damla, Bulut Avşar, Cansu, Uysal, Serhat, Guliyeva, Günel, Başkol, Dilşah, Demir, Melike, Mermer, Sinan, Chousein Memetali, Seichan, Şanlıdağ, Gamze, Mert, Merve, Sipahi, Hilal, Ulusoy, Sercan, Reşat Sipahi, Oğuz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6810696/
http://dx.doi.org/10.1093/ofid/ofz360.294
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author Akyol, Deniz
Uyan Önal, Ayşe
Önal, Uğur
Akdağ, Damla
Bulut Avşar, Cansu
Uysal, Serhat
Guliyeva, Günel
Başkol, Dilşah
Demir, Melike
Mermer, Sinan
Chousein Memetali, Seichan
Şanlıdağ, Gamze
Mert, Merve
Sipahi, Hilal
Ulusoy, Sercan
Reşat Sipahi, Oğuz
author_facet Akyol, Deniz
Uyan Önal, Ayşe
Önal, Uğur
Akdağ, Damla
Bulut Avşar, Cansu
Uysal, Serhat
Guliyeva, Günel
Başkol, Dilşah
Demir, Melike
Mermer, Sinan
Chousein Memetali, Seichan
Şanlıdağ, Gamze
Mert, Merve
Sipahi, Hilal
Ulusoy, Sercan
Reşat Sipahi, Oğuz
author_sort Akyol, Deniz
collection PubMed
description BACKGROUND: In this study it was aimed to compare the effects of qSOFA (Quick Sequential Organ Failure Assessment) score with modified qSOFA score (PLoS One. 2018 Sep 26;13(9):e0204608) for predicting one month survival in patients with diagnosed septic shock (SS) in a tertiary-care educational university hospital in a developing country. METHODS: Modified qSOFA was created by adding age factor (>50 years=1 point) to patients with qSOFA scale 1 or 2 or 3 who had SS (sepsis+hypotension+adrenergic agent) and consulted by Infectious Diseases consultants between December 2013-December 2018. Arterial lactate level of >2 mmol/L criterion was added as an including criteria for SS according to 3(rd) International Sepsis and Septic Shock Consensus Statement after 23(rd) February 2016. Statistical analysis was performed via Chi-square test and a p-value <0.05 was considered significant. RESULTS: The number of patients with qSOFA score of 1 or 2 or 3 from 527 patients are in Table1 [some of the cases were diagnosed as septic shock according to elder definition (without lactate criterion) and there was a subgroup with qSOFA score 1]. Among the >50-year aged group, the 30-day survival rate was lower in patients with qSOFA3 vs. qSOFA 2 vs. qSOFA 1 (Table1, 3x2 Chi Square test, P = 0.0057). Among the <50 years group, the qSOFA one month survival rate was lower in patients with qSOFA 3 vs. qSOFA 2 vs. qSOFA 1 (Table, 3x2 Chi Square Test, P = 0.0052). According to modified qSOFA, there was a significant difference for one month survival among SS cases with scores of 1, 2, 3 and 4 (12/21 57% vs. Fifty/126 40% vs. 78/269 29% vs. 22/111 20%, 4x2 Chi-square test, P = 0.0003). On the other hand, there was no significant difference in terms of one month survival when we performed subgroup analysis in qSOFA score 1, 2, or 3 subgroups, as ≤50 years vs. >50 years (table, Chi-square test, 12/21 vs. 39/97 P = 0.224, 11/29 vs. 75/244 P = 0.526, 3/25 vs. 22/111 P = 0.572). CONCLUSION: In terms of survival at one month, there was a significant difference between qSOFA score 1, 2, 3 and 4 subgroups. In patients with qSOFA score of 1 or 2 or 3, being under 50 years did not have a significant effect on one-month survival. Modified qSOFA may be beneficial to foresee the probable mortality but these findings need to be validated in larger cohorts [Image: see text] DISCLOSURES: All authors: No reported disclosures.
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spelling pubmed-68106962019-10-28 219. Is the modified quick SOFA scale superior to quick SOFA in patients with diagnosed septic shock? Akyol, Deniz Uyan Önal, Ayşe Önal, Uğur Akdağ, Damla Bulut Avşar, Cansu Uysal, Serhat Guliyeva, Günel Başkol, Dilşah Demir, Melike Mermer, Sinan Chousein Memetali, Seichan Şanlıdağ, Gamze Mert, Merve Sipahi, Hilal Ulusoy, Sercan Reşat Sipahi, Oğuz Open Forum Infect Dis Abstracts BACKGROUND: In this study it was aimed to compare the effects of qSOFA (Quick Sequential Organ Failure Assessment) score with modified qSOFA score (PLoS One. 2018 Sep 26;13(9):e0204608) for predicting one month survival in patients with diagnosed septic shock (SS) in a tertiary-care educational university hospital in a developing country. METHODS: Modified qSOFA was created by adding age factor (>50 years=1 point) to patients with qSOFA scale 1 or 2 or 3 who had SS (sepsis+hypotension+adrenergic agent) and consulted by Infectious Diseases consultants between December 2013-December 2018. Arterial lactate level of >2 mmol/L criterion was added as an including criteria for SS according to 3(rd) International Sepsis and Septic Shock Consensus Statement after 23(rd) February 2016. Statistical analysis was performed via Chi-square test and a p-value <0.05 was considered significant. RESULTS: The number of patients with qSOFA score of 1 or 2 or 3 from 527 patients are in Table1 [some of the cases were diagnosed as septic shock according to elder definition (without lactate criterion) and there was a subgroup with qSOFA score 1]. Among the >50-year aged group, the 30-day survival rate was lower in patients with qSOFA3 vs. qSOFA 2 vs. qSOFA 1 (Table1, 3x2 Chi Square test, P = 0.0057). Among the <50 years group, the qSOFA one month survival rate was lower in patients with qSOFA 3 vs. qSOFA 2 vs. qSOFA 1 (Table, 3x2 Chi Square Test, P = 0.0052). According to modified qSOFA, there was a significant difference for one month survival among SS cases with scores of 1, 2, 3 and 4 (12/21 57% vs. Fifty/126 40% vs. 78/269 29% vs. 22/111 20%, 4x2 Chi-square test, P = 0.0003). On the other hand, there was no significant difference in terms of one month survival when we performed subgroup analysis in qSOFA score 1, 2, or 3 subgroups, as ≤50 years vs. >50 years (table, Chi-square test, 12/21 vs. 39/97 P = 0.224, 11/29 vs. 75/244 P = 0.526, 3/25 vs. 22/111 P = 0.572). CONCLUSION: In terms of survival at one month, there was a significant difference between qSOFA score 1, 2, 3 and 4 subgroups. In patients with qSOFA score of 1 or 2 or 3, being under 50 years did not have a significant effect on one-month survival. Modified qSOFA may be beneficial to foresee the probable mortality but these findings need to be validated in larger cohorts [Image: see text] DISCLOSURES: All authors: No reported disclosures. Oxford University Press 2019-10-23 /pmc/articles/PMC6810696/ http://dx.doi.org/10.1093/ofid/ofz360.294 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Abstracts
Akyol, Deniz
Uyan Önal, Ayşe
Önal, Uğur
Akdağ, Damla
Bulut Avşar, Cansu
Uysal, Serhat
Guliyeva, Günel
Başkol, Dilşah
Demir, Melike
Mermer, Sinan
Chousein Memetali, Seichan
Şanlıdağ, Gamze
Mert, Merve
Sipahi, Hilal
Ulusoy, Sercan
Reşat Sipahi, Oğuz
219. Is the modified quick SOFA scale superior to quick SOFA in patients with diagnosed septic shock?
title 219. Is the modified quick SOFA scale superior to quick SOFA in patients with diagnosed septic shock?
title_full 219. Is the modified quick SOFA scale superior to quick SOFA in patients with diagnosed septic shock?
title_fullStr 219. Is the modified quick SOFA scale superior to quick SOFA in patients with diagnosed septic shock?
title_full_unstemmed 219. Is the modified quick SOFA scale superior to quick SOFA in patients with diagnosed septic shock?
title_short 219. Is the modified quick SOFA scale superior to quick SOFA in patients with diagnosed septic shock?
title_sort 219. is the modified quick sofa scale superior to quick sofa in patients with diagnosed septic shock?
topic Abstracts
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6810696/
http://dx.doi.org/10.1093/ofid/ofz360.294
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