726. APX001 (Fosmanogepix) Is Effective in an Immunosuppressed Mouse Model of Rhizopus oryzae Infection

BACKGROUND: Mucormycosis is a life-threatening infection that predominantly occurs in immunocompromised hosts. The antifungal APX001A (manogepix) inhibits Gwt1, an enzyme required for the conserved glycosylphosphatidyl inositol (GPI) post-translational modification in eukaryotes. We previously repor...

Descripción completa

Detalles Bibliográficos
Autores principales: Gebremariam, Teklegiorgis, Alkhazraji, Sondus, Gu, Yiyou, Alqarihi, Abdullah, Mamouei, Zeinab, Shaw, Karen J, Ibrahim, Ashraf S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6810953/
http://dx.doi.org/10.1093/ofid/ofz360.794

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6810953/
http://dx.doi.org/10.1093/ofid/ofz360.794

Ejemplares similares