713. Preventive Administration of MEDI6389, a Combination of Monoclonal Antibodies (mAbs) Targeting Alpha-Toxin (AT), Panton-Valentine Leukocidin (PVL), Leukocidin ED (LukED), Gamma-Hemolysin and Clumping Factor A (ClfA), in a Rabbit Model of USA300 MRSA Prosthetic Joint Infection (PJI)

BACKGROUND: mAbs targeting staphylococcal virulence factors could represent an interesting preventive strategy in PJI. We evaluate here MEDI6389 compared with isotype-matched control IgG (c-IgG) in a rabbit model of USA300 MRSA PJI. METHODS: Rabbits were randomized for prophylaxis with either c-IgG...

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Detalles Bibliográficos
Autores principales: Yanjie, Mao, Valour, Florent, Vu Vi Tran, Giang, Vu, Trang, Delaye, Thomas, Quynh Nhu Nguyen, Tran, Tkaczyk, Christine, Cheng, Li, Sellman, Bret R, An Diep, Binh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6810972/
http://dx.doi.org/10.1093/ofid/ofz360.781

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