733. Pharmacokinetic–Pharmacodynamic (PK–PD) Analyses for Alanine Aminotransferase (ALT) Using Phase 3 Data From Omadacycline (OMC)-Treated Patients

BACKGROUND: OMC, an aminomethylcycline structurally related to tetracycline agents, was recently approved by the US FDA for the treatment of adult patients with ABSSSI (IV-to-PO and PO regimens) and CABP (IV-to-PO regimen). To better understand exposure-related concerns for ALT increase, PK-PD relat...

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Detalles Bibliográficos
Autores principales: Bhavnani, Sujata M, Trang, Michael, George, Darryl R, Liolios, Kathryn, McGovern, Paul C, Friedrich, Lawrence, Steenbergen, Judith N, Rubino, Christopher M, Tzanis, Evan, Ambrose, Paul G, Hammel, Jeffrey P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
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Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6811230/
http://dx.doi.org/10.1093/ofid/ofz360.801

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