Epithelial Lining Fluid and Plasma Concentrations of Dalbavancin in Healthy Adults after a Single 1,500-Milligram Infusion

Dalbavancin is a lipoglycopeptide antibiotic with a prolonged half-life. A phase 1 study assessed dalbavancin levels in epithelial lining fluid (ELF) in 35 healthy adults using ELF bronchial microsampling up to 168 h after administration of 1,500 mg dalbavancin. The penetration of dalbavancin into E...

Descripción completa

Detalles Bibliográficos
Autores principales: Rappo, Urania, Dunne, Michael W., Puttagunta, Sailaja, Baldassarre, James S., Su, Shengfang, Desai-Krieger, Daksha, Inoue, Megumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Clinical Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6811436/
https://www.ncbi.nlm.nih.gov/pubmed/31501147
http://dx.doi.org/10.1128/AAC.01024-19
Descripción
Sumario:Dalbavancin is a lipoglycopeptide antibiotic with a prolonged half-life. A phase 1 study assessed dalbavancin levels in epithelial lining fluid (ELF) in 35 healthy adults using ELF bronchial microsampling up to 168 h after administration of 1,500 mg dalbavancin. The penetration of dalbavancin into ELF was 36%. ELF levels of dalbavancin exceeded the MIC(90)s of Streptococcus pneumoniae and Staphylococcus aureus for ≥7 days.

Ejemplares similares