Epithelial Lining Fluid and Plasma Concentrations of Dalbavancin in Healthy Adults after a Single 1,500-Milligram Infusion

Dalbavancin is a lipoglycopeptide antibiotic with a prolonged half-life. A phase 1 study assessed dalbavancin levels in epithelial lining fluid (ELF) in 35 healthy adults using ELF bronchial microsampling up to 168 h after administration of 1,500 mg dalbavancin. The penetration of dalbavancin into E...

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Autores principales: Rappo, Urania, Dunne, Michael W., Puttagunta, Sailaja, Baldassarre, James S., Su, Shengfang, Desai-Krieger, Daksha, Inoue, Megumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Clinical Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6811436/
https://www.ncbi.nlm.nih.gov/pubmed/31501147
http://dx.doi.org/10.1128/AAC.01024-19
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author Rappo, Urania
Dunne, Michael W.
Puttagunta, Sailaja
Baldassarre, James S.
Su, Shengfang
Desai-Krieger, Daksha
Inoue, Megumi
author_facet Rappo, Urania
Dunne, Michael W.
Puttagunta, Sailaja
Baldassarre, James S.
Su, Shengfang
Desai-Krieger, Daksha
Inoue, Megumi
author_sort Rappo, Urania
collection PubMed
description Dalbavancin is a lipoglycopeptide antibiotic with a prolonged half-life. A phase 1 study assessed dalbavancin levels in epithelial lining fluid (ELF) in 35 healthy adults using ELF bronchial microsampling up to 168 h after administration of 1,500 mg dalbavancin. The penetration of dalbavancin into ELF was 36%. ELF levels of dalbavancin exceeded the MIC(90)s of Streptococcus pneumoniae and Staphylococcus aureus for ≥7 days.
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spelling pubmed-68114362019-11-07 Epithelial Lining Fluid and Plasma Concentrations of Dalbavancin in Healthy Adults after a Single 1,500-Milligram Infusion Rappo, Urania Dunne, Michael W. Puttagunta, Sailaja Baldassarre, James S. Su, Shengfang Desai-Krieger, Daksha Inoue, Megumi Antimicrob Agents Chemother Clinical Therapeutics Dalbavancin is a lipoglycopeptide antibiotic with a prolonged half-life. A phase 1 study assessed dalbavancin levels in epithelial lining fluid (ELF) in 35 healthy adults using ELF bronchial microsampling up to 168 h after administration of 1,500 mg dalbavancin. The penetration of dalbavancin into ELF was 36%. ELF levels of dalbavancin exceeded the MIC(90)s of Streptococcus pneumoniae and Staphylococcus aureus for ≥7 days. American Society for Microbiology 2019-10-22 /pmc/articles/PMC6811436/ /pubmed/31501147 http://dx.doi.org/10.1128/AAC.01024-19 Text en Copyright © 2019 Rappo et al. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Clinical Therapeutics
Rappo, Urania
Dunne, Michael W.
Puttagunta, Sailaja
Baldassarre, James S.
Su, Shengfang
Desai-Krieger, Daksha
Inoue, Megumi
Epithelial Lining Fluid and Plasma Concentrations of Dalbavancin in Healthy Adults after a Single 1,500-Milligram Infusion
title Epithelial Lining Fluid and Plasma Concentrations of Dalbavancin in Healthy Adults after a Single 1,500-Milligram Infusion
title_full Epithelial Lining Fluid and Plasma Concentrations of Dalbavancin in Healthy Adults after a Single 1,500-Milligram Infusion
title_fullStr Epithelial Lining Fluid and Plasma Concentrations of Dalbavancin in Healthy Adults after a Single 1,500-Milligram Infusion
title_full_unstemmed Epithelial Lining Fluid and Plasma Concentrations of Dalbavancin in Healthy Adults after a Single 1,500-Milligram Infusion
title_short Epithelial Lining Fluid and Plasma Concentrations of Dalbavancin in Healthy Adults after a Single 1,500-Milligram Infusion
title_sort epithelial lining fluid and plasma concentrations of dalbavancin in healthy adults after a single 1,500-milligram infusion
topic Clinical Therapeutics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6811436/
https://www.ncbi.nlm.nih.gov/pubmed/31501147
http://dx.doi.org/10.1128/AAC.01024-19
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