Lactic Acidosis Promotes Mitochondrial Biogenesis in Lung Adenocarcinoma Cells, Supporting Proliferation Under Normoxia or Survival Under Hypoxia

Lactic acidosis, glucose deprivation and hypoxia are conditions frequently found in solid tumors because, among other reasons, tumors switch to Warburg effect and secrete high levels of lactate, which decreases the pH (<6. 9) in the microenvironment. We hypothesized that lung cancer cells consume...

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Detalles Bibliográficos
Autores principales: Romero-Garcia, Susana, Prado-Garcia, Heriberto, Valencia-Camargo, Alma Delia, Alvarez-Pulido, Abraham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6811519/
https://www.ncbi.nlm.nih.gov/pubmed/31681589
http://dx.doi.org/10.3389/fonc.2019.01053

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6811519/
https://www.ncbi.nlm.nih.gov/pubmed/31681589
http://dx.doi.org/10.3389/fonc.2019.01053

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