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Tetraploidy causes chromosomal instability in acentriolar mouse embryos
Tetraploidisation is considered a common event in the evolution of chromosomal instability (CIN) in cancer cells. The current model for how tetraploidy drives CIN in mammalian cells is that a doubling of the number of centrioles that accompany the genome doubling event leads to multipolar spindle fo...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6811537/ https://www.ncbi.nlm.nih.gov/pubmed/31645568 http://dx.doi.org/10.1038/s41467-019-12772-8 |