Cargando…
Inverting family GH156 sialidases define an unusual catalytic motif for glycosidase action
Sialic acids are a family of related sugars that play essential roles in many biological events intimately linked to cellular recognition in both health and disease. Sialidases are therefore orchestrators of cellular biology and important therapeutic targets for viral infection. Here, we sought to d...
Autores principales: | Bule, Pedro, Chuzel, Léa, Blagova, Elena, Wu, Liang, Gray, Melissa A., Henrissat, Bernard, Rapp, Erdmann, Bertozzi, Carolyn R., Taron, Christopher H., Davies, Gideon J. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6811678/ https://www.ncbi.nlm.nih.gov/pubmed/31645552 http://dx.doi.org/10.1038/s41467-019-12684-7 |
Ejemplares similares
-
Functional metagenomics identifies an exosialidase with an inverting catalytic mechanism that defines a new glycoside hydrolase family (GH156)
por: Chuzel, Léa, et al.
Publicado: (2018) -
Divergence of Catalytic Mechanism within a Glycosidase Family Provides Insight into Evolution of Carbohydrate Metabolism by Human Gut Flora
por: Gloster, Tracey M., et al.
Publicado: (2008) -
Gut bacteria responding to dietary change encode sialidases that exhibit preference for red meat-associated carbohydrates
por: Zaramela, Livia S., et al.
Publicado: (2019) -
Molecular Dynamics Simulations Reveal the Conformational Transition of GH33 Sialidases
por: Cao, Xueting, et al.
Publicado: (2023) -
Probing the role of an invariant active site His in family GH1 β-glycosidases
por: Strazzulli, Andrea, et al.
Publicado: (2019)