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Practical considerations for the implementation of adaptive designs for oncology Phase I dose-finding trials
The traditional 3 + 3 design continues to be commonly used for Phase I dose-finding oncology trials, despite increasing criticisms and development of innovative methods. Unfortunately, it is a challenge to convince principal investigators to use novel designs. The goal of this paper is to persuade r...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Newlands Press Ltd
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6811732/ https://www.ncbi.nlm.nih.gov/pubmed/31656956 http://dx.doi.org/10.4155/fdd-2019-0021 |