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Potent, selective, and subunit‐dependent activation of TRPC5 channels by a xanthine derivative

BACKGROUND AND PURPOSE: The TRPC1, TRPC4, and TRPC5 proteins form homotetrameric or heterotetrameric, calcium‐permeable cation channels that are involved in various disease states. Recent research has yielded specific and potent xanthine‐based TRPC1/4/5 inhibitors. Here, we investigated the possibil...

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Detalles Bibliográficos
Autores principales:	Minard, Aisling, Bauer, Claudia C., Chuntharpursat‐Bon, Eulashini, Pickles, Isabelle B., Wright, David J., Ludlow, Melanie J., Burnham, Matthew P., Warriner, Stuart L., Beech, David J., Muraki, Katsuhiko, Bon, Robin S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6811774/ https://www.ncbi.nlm.nih.gov/pubmed/31277085 http://dx.doi.org/10.1111/bph.14791

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