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Investigations into the Influence of Solvents on the Nucleation Kinetics for Isonicotinamide, Lovastatin, and Phenacetin
[Image: see text] A new method of data interpretation based on classical nucleation theory is proposed in this work to elucidate the influence of solvents on the pre-exponential nucleation factor and interfacial energy using the induction time data for three crystallization systems, including isonic...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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American Chemical Society
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6811862/ https://www.ncbi.nlm.nih.gov/pubmed/31656908 http://dx.doi.org/10.1021/acsomega.9b02102 |
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author | Shiau, Lie-Ding |
author_facet | Shiau, Lie-Ding |
author_sort | Shiau, Lie-Ding |
collection | PubMed |
description | [Image: see text] A new method of data interpretation based on classical nucleation theory is proposed in this work to elucidate the influence of solvents on the pre-exponential nucleation factor and interfacial energy using the induction time data for three crystallization systems, including isonicotinamide, lovastatin, and phenacetin. In this method, the pre-exponential nucleation factor is replaced by the intrinsic nucleation factor multiplied by temperature and divided by solution viscosity. The proposed method is applied to study the nucleation kinetics of isonicotinamide, lovastatin, and phenacetin among various solvents using the induction time data measured in this work. The results indicate that the intrinsic nucleation factor increases linearly with increasing square root of interfacial energy in various solvents for each system. |
format | Online Article Text |
id | pubmed-6811862 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-68118622019-10-25 Investigations into the Influence of Solvents on the Nucleation Kinetics for Isonicotinamide, Lovastatin, and Phenacetin Shiau, Lie-Ding ACS Omega [Image: see text] A new method of data interpretation based on classical nucleation theory is proposed in this work to elucidate the influence of solvents on the pre-exponential nucleation factor and interfacial energy using the induction time data for three crystallization systems, including isonicotinamide, lovastatin, and phenacetin. In this method, the pre-exponential nucleation factor is replaced by the intrinsic nucleation factor multiplied by temperature and divided by solution viscosity. The proposed method is applied to study the nucleation kinetics of isonicotinamide, lovastatin, and phenacetin among various solvents using the induction time data measured in this work. The results indicate that the intrinsic nucleation factor increases linearly with increasing square root of interfacial energy in various solvents for each system. American Chemical Society 2019-10-10 /pmc/articles/PMC6811862/ /pubmed/31656908 http://dx.doi.org/10.1021/acsomega.9b02102 Text en Copyright © 2019 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes. |
spellingShingle | Shiau, Lie-Ding Investigations into the Influence of Solvents on the Nucleation Kinetics for Isonicotinamide, Lovastatin, and Phenacetin |
title | Investigations into the Influence of
Solvents on the Nucleation Kinetics for Isonicotinamide, Lovastatin,
and Phenacetin |
title_full | Investigations into the Influence of
Solvents on the Nucleation Kinetics for Isonicotinamide, Lovastatin,
and Phenacetin |
title_fullStr | Investigations into the Influence of
Solvents on the Nucleation Kinetics for Isonicotinamide, Lovastatin,
and Phenacetin |
title_full_unstemmed | Investigations into the Influence of
Solvents on the Nucleation Kinetics for Isonicotinamide, Lovastatin,
and Phenacetin |
title_short | Investigations into the Influence of
Solvents on the Nucleation Kinetics for Isonicotinamide, Lovastatin,
and Phenacetin |
title_sort | investigations into the influence of
solvents on the nucleation kinetics for isonicotinamide, lovastatin,
and phenacetin |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6811862/ https://www.ncbi.nlm.nih.gov/pubmed/31656908 http://dx.doi.org/10.1021/acsomega.9b02102 |
work_keys_str_mv | AT shiaulieding investigationsintotheinfluenceofsolventsonthenucleationkineticsforisonicotinamidelovastatinandphenacetin |