Genome-wide DNA methylation data from adult brain following prenatal immune activation and dietary intervention

DNA methylation is a dynamic epigenetic mark regulating gene function and are implicated in the pathophysiology of schizophrenia and autism. Environmental exposures such as inflammation and diet modify the epigenome and may explain why prenatal exposure to inflammation increase risk of neurodevelopm...

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Detalles Bibliográficos
Autores principales: Basil, Paul, Li, Qi, McAlonan, Grainne M., Sham, Pak-Chung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Biochemistry, Genetics and Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6811979/
https://www.ncbi.nlm.nih.gov/pubmed/31667312
http://dx.doi.org/10.1016/j.dib.2019.104561
Descripción
Sumario:DNA methylation is a dynamic epigenetic mark regulating gene function and are implicated in the pathophysiology of schizophrenia and autism. Environmental exposures such as inflammation and diet modify the epigenome and may explain why prenatal exposure to inflammation increase risk of neurodevelopmental disorders. This manuscript presents genome-wide DNA methylation data (GSE102942) generated from adult offspring brain prenatally exposed to Maternal Immune Activation (MIA). Methylome of the adult brain supplemented with omega-3 polyunsaturated fatty acids (PUFA) is also described. DNA methylation across gene regulatory regions were measured using MSP-I digestion and Reduced Representation Bisulfite Sequencing (RRBS) method.

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