Genome-wide DNA methylation data from adult brain following prenatal immune activation and dietary intervention

DNA methylation is a dynamic epigenetic mark regulating gene function and are implicated in the pathophysiology of schizophrenia and autism. Environmental exposures such as inflammation and diet modify the epigenome and may explain why prenatal exposure to inflammation increase risk of neurodevelopm...

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Autores principales: Basil, Paul, Li, Qi, McAlonan, Grainne M., Sham, Pak-Chung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Biochemistry, Genetics and Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6811979/
https://www.ncbi.nlm.nih.gov/pubmed/31667312
http://dx.doi.org/10.1016/j.dib.2019.104561
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author Basil, Paul
Li, Qi
McAlonan, Grainne M.
Sham, Pak-Chung
author_facet Basil, Paul
Li, Qi
McAlonan, Grainne M.
Sham, Pak-Chung
author_sort Basil, Paul
collection PubMed
description DNA methylation is a dynamic epigenetic mark regulating gene function and are implicated in the pathophysiology of schizophrenia and autism. Environmental exposures such as inflammation and diet modify the epigenome and may explain why prenatal exposure to inflammation increase risk of neurodevelopmental disorders. This manuscript presents genome-wide DNA methylation data (GSE102942) generated from adult offspring brain prenatally exposed to Maternal Immune Activation (MIA). Methylome of the adult brain supplemented with omega-3 polyunsaturated fatty acids (PUFA) is also described. DNA methylation across gene regulatory regions were measured using MSP-I digestion and Reduced Representation Bisulfite Sequencing (RRBS) method.
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spelling pubmed-68119792019-10-30 Genome-wide DNA methylation data from adult brain following prenatal immune activation and dietary intervention Basil, Paul Li, Qi McAlonan, Grainne M. Sham, Pak-Chung Data Brief Biochemistry, Genetics and Molecular Biology DNA methylation is a dynamic epigenetic mark regulating gene function and are implicated in the pathophysiology of schizophrenia and autism. Environmental exposures such as inflammation and diet modify the epigenome and may explain why prenatal exposure to inflammation increase risk of neurodevelopmental disorders. This manuscript presents genome-wide DNA methylation data (GSE102942) generated from adult offspring brain prenatally exposed to Maternal Immune Activation (MIA). Methylome of the adult brain supplemented with omega-3 polyunsaturated fatty acids (PUFA) is also described. DNA methylation across gene regulatory regions were measured using MSP-I digestion and Reduced Representation Bisulfite Sequencing (RRBS) method. Elsevier 2019-09-26 /pmc/articles/PMC6811979/ /pubmed/31667312 http://dx.doi.org/10.1016/j.dib.2019.104561 Text en © 2019 Published by Elsevier Inc. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Biochemistry, Genetics and Molecular Biology
Basil, Paul
Li, Qi
McAlonan, Grainne M.
Sham, Pak-Chung
Genome-wide DNA methylation data from adult brain following prenatal immune activation and dietary intervention
title Genome-wide DNA methylation data from adult brain following prenatal immune activation and dietary intervention
title_full Genome-wide DNA methylation data from adult brain following prenatal immune activation and dietary intervention
title_fullStr Genome-wide DNA methylation data from adult brain following prenatal immune activation and dietary intervention
title_full_unstemmed Genome-wide DNA methylation data from adult brain following prenatal immune activation and dietary intervention
title_short Genome-wide DNA methylation data from adult brain following prenatal immune activation and dietary intervention
title_sort genome-wide dna methylation data from adult brain following prenatal immune activation and dietary intervention
topic Biochemistry, Genetics and Molecular Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6811979/
https://www.ncbi.nlm.nih.gov/pubmed/31667312
http://dx.doi.org/10.1016/j.dib.2019.104561
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