Cysteine oxidation triggers amyloid fibril formation of the tumor suppressor p16(INK4A)

The tumor suppressor p16(INK4A) induces cell cycle arrest and senescence in response to oncogenic transformation and is therefore frequently lost in cancer. p16(INK4A) is also known to accumulate under conditions of oxidative stress. Thus, we hypothesized it could potentially be regulated by reversi...

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Detalles Bibliográficos
Autores principales: Göbl, Christoph, Morris, Vanessa K., van Dam, Loes, Visscher, Marieke, Polderman, Paulien E., Hartlmüller, Christoph, de Ruiter, Hesther, Hora, Manuel, Liesinger, Laura, Birner-Gruenberger, Ruth, Vos, Harmjan R., Reif, Bernd, Madl, Tobias, Dansen, Tobias B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812003/
https://www.ncbi.nlm.nih.gov/pubmed/31539802
http://dx.doi.org/10.1016/j.redox.2019.101316

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