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Multistep Solvent-Free 3 m(2) Footprint Pilot Miniplant for the Synthesis of Annual Half-Ton Rufinamide Precursor

[Image: see text] The development of a pilot-scale synthesis of the rufinamide precursor in flow chemistry is reported. Complex steps such as Taylor-flow, segmented flow, and high-temperature processing at high pressure (high-p,T) are successfully combined, overcoming the mixing and heat transfer is...

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Detalles Bibliográficos
Autores principales: Escribà-Gelonch, Marc, de Leon Izeppi, Gerardo Antonio, Kirschneck, Dirk, Hessel, Volker
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812013/
https://www.ncbi.nlm.nih.gov/pubmed/31656707
http://dx.doi.org/10.1021/acssuschemeng.9b03931