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Multistep Solvent-Free 3 m(2) Footprint Pilot Miniplant for the Synthesis of Annual Half-Ton Rufinamide Precursor
[Image: see text] The development of a pilot-scale synthesis of the rufinamide precursor in flow chemistry is reported. Complex steps such as Taylor-flow, segmented flow, and high-temperature processing at high pressure (high-p,T) are successfully combined, overcoming the mixing and heat transfer is...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American
Chemical Society
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812013/ https://www.ncbi.nlm.nih.gov/pubmed/31656707 http://dx.doi.org/10.1021/acssuschemeng.9b03931 |