Cargando…

PVCTools: parallel variation calling tools

As the development of sequencing technology, it is now possible to sequence individuals of each species. Although a number of different tools have been developed to detect individual variations, most of them cannot be run in parallel modes. To accelerate variation detection, PVCTools is introduced i...

Descripción completa

Detalles Bibliográficos
Autores principales: Jin, Jingjing, Liu, Jiajun, Yin, Yelin, Li, Zefeng, Lu, Peng, Xu, Yalong, Zhang, Jianfeng, Cao, Peijian, Hu, Dasha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812194/
https://www.ncbi.nlm.nih.gov/pubmed/31667383
http://dx.doi.org/10.1016/j.heliyon.2019.e02530
Descripción
Sumario:As the development of sequencing technology, it is now possible to sequence individuals of each species. Although a number of different tools have been developed to detect individual variations, most of them cannot be run in parallel modes. To accelerate variation detection, PVCTools is introduced in this study. PVCTools splits the reference genome and alignment files into small pieces and runs them in parallel mode. Meanwhile, boundary noise is also considered in PVCTools. From the result of three different sets of test data, PVCTools performs much faster than most other current tools. At the same time, it keeps similar accuracy with other tools. PVCTools is free and open source software. The development of sequencing technology and growing sample numbers will make performance improvements such as PVCTools increasingly interesting.