Antimicrobial and wound healing properties of a bacterial cellulose based material containing B. subtilis cells

A biocomposite composed of bacterial cellulose (BC) gel-film and Bacillus subtilis (BS) cells was obtained and characterized with a view to future biomedical applications. The inclusion of functional ingredient (10(10)/g viable BS cells) in the composite was carried out by their joint aggregation wi...

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Detalles Bibliográficos
Autores principales: Savitskaya, I.S., Shokatayeva, D.H., Kistaubayeva, A.S., Ignatova, L.V., Digel, I.E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812235/
https://www.ncbi.nlm.nih.gov/pubmed/31667414
http://dx.doi.org/10.1016/j.heliyon.2019.e02592
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author Savitskaya, I.S.
Shokatayeva, D.H.
Kistaubayeva, A.S.
Ignatova, L.V.
Digel, I.E.
author_facet Savitskaya, I.S.
Shokatayeva, D.H.
Kistaubayeva, A.S.
Ignatova, L.V.
Digel, I.E.
author_sort Savitskaya, I.S.
collection PubMed
description A biocomposite composed of bacterial cellulose (BC) gel-film and Bacillus subtilis (BS) cells was obtained and characterized with a view to future biomedical applications. The inclusion of functional ingredient (10(10)/g viable BS cells) in the composite was carried out by their joint aggregation with the BC gel-film. Immobilized BS cells displayed high antagonistic activity towards causative agents of wound infections such as Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Pseudomonas aeruginosa. Application of the BC/BS-biocomposite for the treatment of excision wounds, performed on laboratory animals, stimulated reparative processes and shortened the healing time. Possible mechanisms of the wound-healing effect of BC/BS gel films are discussed. In this work we claim that the developed BC/BS-material can be positioned as a universal wound coating and sanitary-hygienic product.
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spelling pubmed-68122352019-10-30 Antimicrobial and wound healing properties of a bacterial cellulose based material containing B. subtilis cells Savitskaya, I.S. Shokatayeva, D.H. Kistaubayeva, A.S. Ignatova, L.V. Digel, I.E. Heliyon Article A biocomposite composed of bacterial cellulose (BC) gel-film and Bacillus subtilis (BS) cells was obtained and characterized with a view to future biomedical applications. The inclusion of functional ingredient (10(10)/g viable BS cells) in the composite was carried out by their joint aggregation with the BC gel-film. Immobilized BS cells displayed high antagonistic activity towards causative agents of wound infections such as Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Pseudomonas aeruginosa. Application of the BC/BS-biocomposite for the treatment of excision wounds, performed on laboratory animals, stimulated reparative processes and shortened the healing time. Possible mechanisms of the wound-healing effect of BC/BS gel films are discussed. In this work we claim that the developed BC/BS-material can be positioned as a universal wound coating and sanitary-hygienic product. Elsevier 2019-10-10 /pmc/articles/PMC6812235/ /pubmed/31667414 http://dx.doi.org/10.1016/j.heliyon.2019.e02592 Text en © 2019 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Savitskaya, I.S.
Shokatayeva, D.H.
Kistaubayeva, A.S.
Ignatova, L.V.
Digel, I.E.
Antimicrobial and wound healing properties of a bacterial cellulose based material containing B. subtilis cells
title Antimicrobial and wound healing properties of a bacterial cellulose based material containing B. subtilis cells
title_full Antimicrobial and wound healing properties of a bacterial cellulose based material containing B. subtilis cells
title_fullStr Antimicrobial and wound healing properties of a bacterial cellulose based material containing B. subtilis cells
title_full_unstemmed Antimicrobial and wound healing properties of a bacterial cellulose based material containing B. subtilis cells
title_short Antimicrobial and wound healing properties of a bacterial cellulose based material containing B. subtilis cells
title_sort antimicrobial and wound healing properties of a bacterial cellulose based material containing b. subtilis cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812235/
https://www.ncbi.nlm.nih.gov/pubmed/31667414
http://dx.doi.org/10.1016/j.heliyon.2019.e02592
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AT ignatovalv antimicrobialandwoundhealingpropertiesofabacterialcellulosebasedmaterialcontainingbsubtiliscells
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