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Sleep-wake stages classification using heart rate signals from pulse oximetry
The most important index of obstructive sleep apnea/hypopnea syndrome (OSAHS) is the apnea/hyponea index (AHI). The AHI is the number of apnea/hypopnea events per hour of sleep. Algorithms for the screening of OSAHS from pulse oximetry estimate an approximation to AHI counting the desaturation event...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812238/ https://www.ncbi.nlm.nih.gov/pubmed/31667382 http://dx.doi.org/10.1016/j.heliyon.2019.e02529 |
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author | Casal, Ramiro Di Persia, Leandro E. Schlotthauer, Gastón |
author_facet | Casal, Ramiro Di Persia, Leandro E. Schlotthauer, Gastón |
author_sort | Casal, Ramiro |
collection | PubMed |
description | The most important index of obstructive sleep apnea/hypopnea syndrome (OSAHS) is the apnea/hyponea index (AHI). The AHI is the number of apnea/hypopnea events per hour of sleep. Algorithms for the screening of OSAHS from pulse oximetry estimate an approximation to AHI counting the desaturation events without consider the sleep stage of the patient. This paper presents an automatic system to determine if a patient is awake or asleep using heart rate (HR) signals provided by pulse oximetry. In this study, 70 features are estimated using entropy and complexity measures, frequency domain and time-scale domain methods, and classical statistics. The dimension of feature space is reduced from 70 to 40 using three different schemes based on forward feature selection with support vector machine and feature importance with random forest. The algorithms were designed, trained and tested with 5000 patients from the Sleep Heart Health Study database. In the test stage, 10-fold cross validation method was applied obtaining performances up to 85.2% accuracy, 88.3% specificity, 79.0% sensitivity, 67.0% positive predictive value, and 91.3% negative predictive value. The results are encouraging, showing the possibility of using HR signals obtained from the same oximeter to determine the sleep stage of the patient, and thus potentially improving the estimation of AHI based on only pulse oximetry. |
format | Online Article Text |
id | pubmed-6812238 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-68122382019-10-30 Sleep-wake stages classification using heart rate signals from pulse oximetry Casal, Ramiro Di Persia, Leandro E. Schlotthauer, Gastón Heliyon Article The most important index of obstructive sleep apnea/hypopnea syndrome (OSAHS) is the apnea/hyponea index (AHI). The AHI is the number of apnea/hypopnea events per hour of sleep. Algorithms for the screening of OSAHS from pulse oximetry estimate an approximation to AHI counting the desaturation events without consider the sleep stage of the patient. This paper presents an automatic system to determine if a patient is awake or asleep using heart rate (HR) signals provided by pulse oximetry. In this study, 70 features are estimated using entropy and complexity measures, frequency domain and time-scale domain methods, and classical statistics. The dimension of feature space is reduced from 70 to 40 using three different schemes based on forward feature selection with support vector machine and feature importance with random forest. The algorithms were designed, trained and tested with 5000 patients from the Sleep Heart Health Study database. In the test stage, 10-fold cross validation method was applied obtaining performances up to 85.2% accuracy, 88.3% specificity, 79.0% sensitivity, 67.0% positive predictive value, and 91.3% negative predictive value. The results are encouraging, showing the possibility of using HR signals obtained from the same oximeter to determine the sleep stage of the patient, and thus potentially improving the estimation of AHI based on only pulse oximetry. Elsevier 2019-10-02 /pmc/articles/PMC6812238/ /pubmed/31667382 http://dx.doi.org/10.1016/j.heliyon.2019.e02529 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Casal, Ramiro Di Persia, Leandro E. Schlotthauer, Gastón Sleep-wake stages classification using heart rate signals from pulse oximetry |
title | Sleep-wake stages classification using heart rate signals from pulse oximetry |
title_full | Sleep-wake stages classification using heart rate signals from pulse oximetry |
title_fullStr | Sleep-wake stages classification using heart rate signals from pulse oximetry |
title_full_unstemmed | Sleep-wake stages classification using heart rate signals from pulse oximetry |
title_short | Sleep-wake stages classification using heart rate signals from pulse oximetry |
title_sort | sleep-wake stages classification using heart rate signals from pulse oximetry |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812238/ https://www.ncbi.nlm.nih.gov/pubmed/31667382 http://dx.doi.org/10.1016/j.heliyon.2019.e02529 |
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