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A simple method to disrupt and restore subunit interaction of acyl-CoA:cholesterol acyltransferase 1
Acyl-CoA:cholestereol acyltransferase 1 (ACAT1) is a two-fold dimer (homotetramer) and has two distinct dimerization domains. One domain is in an alpha-helical rich region near the cytoplasmic N-terminus. The other is proposed to be near the C-terminus where multiple transmembrane domains promote hy...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812321/ https://www.ncbi.nlm.nih.gov/pubmed/31667125 http://dx.doi.org/10.1016/j.mex.2019.09.021 |