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Impaired adult hippocampal neurogenesis in a mouse model of familial hypercholesterolemia: A role for the LDL receptor and cholesterol metabolism in adult neural precursor cells

OBJECTIVE: In familial hypercholesterolemia (FH), mutations in the low-density lipoprotein (LDL) receptor (LDLr) gene result in increased plasma LDL cholesterol. Clinical and preclinical studies have revealed an association between FH and hippocampus-related memory and mood impairment. We here asked...

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Detalles Bibliográficos
Autores principales:	Engel, Daiane F., Grzyb, Anna N., de Oliveira, Jade, Pötzsch, Alexandra, Walker, Tara L., Brocardo, Patricia S., Kempermann, Gerd, de Bem, Andreza F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812372/ https://www.ncbi.nlm.nih.gov/pubmed/31767163 http://dx.doi.org/10.1016/j.molmet.2019.09.002

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