Calcineurin-Modulated Antimicrobial Peptide Expression Is Required for the Development of Helicoverpa armigera

Helicoverpa armigera is a universal pest around the world that has been extensively used as a model organism for agricultural pests. Calcineurin (CAN) is an important Ca(2+)-dependent phosphatase that is participated in various biological pathways. Here, we revealed that CAN inhibition significantly...

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Autores principales: Wei, Jizhen, Li, Linhong, Yao, Shuangyan, Yang, Shuo, Zhou, Shuai, Liu, Xiaoguang, Du, Mengfang, An, Shiheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812685/
https://www.ncbi.nlm.nih.gov/pubmed/31681018
http://dx.doi.org/10.3389/fphys.2019.01312
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author Wei, Jizhen
Li, Linhong
Yao, Shuangyan
Yang, Shuo
Zhou, Shuai
Liu, Xiaoguang
Du, Mengfang
An, Shiheng
author_facet Wei, Jizhen
Li, Linhong
Yao, Shuangyan
Yang, Shuo
Zhou, Shuai
Liu, Xiaoguang
Du, Mengfang
An, Shiheng
author_sort Wei, Jizhen
collection PubMed
description Helicoverpa armigera is a universal pest around the world that has been extensively used as a model organism for agricultural pests. Calcineurin (CAN) is an important Ca(2+)-dependent phosphatase that is participated in various biological pathways. Here, we revealed that CAN inhibition significantly arrested H. armigera larval development by reducing larvae weight, prolonging development time and reducing pupate rates. Furthermore, CAN serves as an immune activator and regulates antimicrobial peptide (AMP; cecropin D, attacin, and gloverin) expression by binding with relish transcript factor in H. armigera. This study provides a potential target to control H. armigera by using synergistic agents for pesticides or plant-mediated RNA interference technology.
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spelling pubmed-68126852019-11-01 Calcineurin-Modulated Antimicrobial Peptide Expression Is Required for the Development of Helicoverpa armigera Wei, Jizhen Li, Linhong Yao, Shuangyan Yang, Shuo Zhou, Shuai Liu, Xiaoguang Du, Mengfang An, Shiheng Front Physiol Physiology Helicoverpa armigera is a universal pest around the world that has been extensively used as a model organism for agricultural pests. Calcineurin (CAN) is an important Ca(2+)-dependent phosphatase that is participated in various biological pathways. Here, we revealed that CAN inhibition significantly arrested H. armigera larval development by reducing larvae weight, prolonging development time and reducing pupate rates. Furthermore, CAN serves as an immune activator and regulates antimicrobial peptide (AMP; cecropin D, attacin, and gloverin) expression by binding with relish transcript factor in H. armigera. This study provides a potential target to control H. armigera by using synergistic agents for pesticides or plant-mediated RNA interference technology. Frontiers Media S.A. 2019-10-17 /pmc/articles/PMC6812685/ /pubmed/31681018 http://dx.doi.org/10.3389/fphys.2019.01312 Text en Copyright © 2019 Wei, Li, Yao, Yang, Zhou, Liu, Du and An. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Wei, Jizhen
Li, Linhong
Yao, Shuangyan
Yang, Shuo
Zhou, Shuai
Liu, Xiaoguang
Du, Mengfang
An, Shiheng
Calcineurin-Modulated Antimicrobial Peptide Expression Is Required for the Development of Helicoverpa armigera
title Calcineurin-Modulated Antimicrobial Peptide Expression Is Required for the Development of Helicoverpa armigera
title_full Calcineurin-Modulated Antimicrobial Peptide Expression Is Required for the Development of Helicoverpa armigera
title_fullStr Calcineurin-Modulated Antimicrobial Peptide Expression Is Required for the Development of Helicoverpa armigera
title_full_unstemmed Calcineurin-Modulated Antimicrobial Peptide Expression Is Required for the Development of Helicoverpa armigera
title_short Calcineurin-Modulated Antimicrobial Peptide Expression Is Required for the Development of Helicoverpa armigera
title_sort calcineurin-modulated antimicrobial peptide expression is required for the development of helicoverpa armigera
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812685/
https://www.ncbi.nlm.nih.gov/pubmed/31681018
http://dx.doi.org/10.3389/fphys.2019.01312
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