A Physiologically‐Based Pharmacokinetic Model for the Prediction of Monoclonal Antibody Pharmacokinetics From In Vitro Data

Monoclonal antibody (mAb) pharmacokinetics (PK) have largely been predicted via allometric scaling with little consideration for cross‐species differences in neonatal Fc receptor (FcRn) affinity or clearance/distribution mechanisms. To address this, we developed a mAb physiologically‐based PK model...

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Detalles Bibliográficos
Autores principales: Jones, Hannah M., Zhang, Zhiwei, Jasper, Paul, Luo, Haobin, Avery, Lindsay B., King, Lindsay E., Neubert, Hendrik, Barton, Hugh A., Betts, Alison M., Webster, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813168/
https://www.ncbi.nlm.nih.gov/pubmed/31464379
http://dx.doi.org/10.1002/psp4.12461

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