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Altered Functional Connectivity of Striatum Based on the Integrated Connectivity Model in First-Episode Schizophrenia
Background: The human striatum is a heterogeneous structure involved in diverse functional domains that related to distinct striatum subregions. Striatal dysfunction was thought to be a fundamental element in schizophrenia. However, the connectivity pattern of striatum solely based on functional or...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813199/ https://www.ncbi.nlm.nih.gov/pubmed/31681050 http://dx.doi.org/10.3389/fpsyt.2019.00756 |
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author | Zhang, Bei Lin, Pan Wang, Xiaosheng Öngür, Dost Ji, Xinlei Situ, Weijun Yao, Shuqiao Wang, Xiang |
author_facet | Zhang, Bei Lin, Pan Wang, Xiaosheng Öngür, Dost Ji, Xinlei Situ, Weijun Yao, Shuqiao Wang, Xiang |
author_sort | Zhang, Bei |
collection | PubMed |
description | Background: The human striatum is a heterogeneous structure involved in diverse functional domains that related to distinct striatum subregions. Striatal dysfunction was thought to be a fundamental element in schizophrenia. However, the connectivity pattern of striatum solely based on functional or structural characteristics leads to inconsistent findings in healthy adult and also schizophrenia. This study aims to develop an integrated striatal model and reveal the altered functional connectivity pattern of the striatum in schizophrenia. Methods: Two data-driven approaches, task-dependent meta-analytic connectivity modeling (MACM) and task-independent resting-state functional connectivity (RSFC), were used for seven anatomical connectivity-based striatum subregions to provide an integrated striatal model. Then, RSFC analyses of seven striatal subregions were applied to 45 first-episode schizophrenia (FES) and 27 healthy controls to examine the difference, based on the integrated model, of functional connectivity pattern of striatal subregions. Results: MACM and RSFC results showed that striatum subregions were associated with discrete cortical regions and involved in distinct cognitive processes. Besides, RSFC results overlapped with MACM findings but showed broader distributions. Importantly, significantly reduced functional connectivity was identified between limbic subregion and thalamus, medial prefrontal cortex, anterior cingulate cortex, and insula and also between executive subregions and thalamus, supplementary motor area, and insula in FES. Conclusions: Combing functional and structural connectivity information, this study provides the integrated model of corticostriatal subcircuits and confirms the abnormal functional connectivity of limbic and executive striatum subregions with different networks and thalamus, supporting the important role of the corticostriatal-thalamic loop in the pathophysiology of schizophrenia. |
format | Online Article Text |
id | pubmed-6813199 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-68131992019-11-01 Altered Functional Connectivity of Striatum Based on the Integrated Connectivity Model in First-Episode Schizophrenia Zhang, Bei Lin, Pan Wang, Xiaosheng Öngür, Dost Ji, Xinlei Situ, Weijun Yao, Shuqiao Wang, Xiang Front Psychiatry Psychiatry Background: The human striatum is a heterogeneous structure involved in diverse functional domains that related to distinct striatum subregions. Striatal dysfunction was thought to be a fundamental element in schizophrenia. However, the connectivity pattern of striatum solely based on functional or structural characteristics leads to inconsistent findings in healthy adult and also schizophrenia. This study aims to develop an integrated striatal model and reveal the altered functional connectivity pattern of the striatum in schizophrenia. Methods: Two data-driven approaches, task-dependent meta-analytic connectivity modeling (MACM) and task-independent resting-state functional connectivity (RSFC), were used for seven anatomical connectivity-based striatum subregions to provide an integrated striatal model. Then, RSFC analyses of seven striatal subregions were applied to 45 first-episode schizophrenia (FES) and 27 healthy controls to examine the difference, based on the integrated model, of functional connectivity pattern of striatal subregions. Results: MACM and RSFC results showed that striatum subregions were associated with discrete cortical regions and involved in distinct cognitive processes. Besides, RSFC results overlapped with MACM findings but showed broader distributions. Importantly, significantly reduced functional connectivity was identified between limbic subregion and thalamus, medial prefrontal cortex, anterior cingulate cortex, and insula and also between executive subregions and thalamus, supplementary motor area, and insula in FES. Conclusions: Combing functional and structural connectivity information, this study provides the integrated model of corticostriatal subcircuits and confirms the abnormal functional connectivity of limbic and executive striatum subregions with different networks and thalamus, supporting the important role of the corticostriatal-thalamic loop in the pathophysiology of schizophrenia. Frontiers Media S.A. 2019-10-18 /pmc/articles/PMC6813199/ /pubmed/31681050 http://dx.doi.org/10.3389/fpsyt.2019.00756 Text en Copyright © 2019 Zhang, Lin, Wang, Öngür, Ji, Situ, Yao and Wang http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychiatry Zhang, Bei Lin, Pan Wang, Xiaosheng Öngür, Dost Ji, Xinlei Situ, Weijun Yao, Shuqiao Wang, Xiang Altered Functional Connectivity of Striatum Based on the Integrated Connectivity Model in First-Episode Schizophrenia |
title | Altered Functional Connectivity of Striatum Based on the Integrated Connectivity Model in First-Episode Schizophrenia |
title_full | Altered Functional Connectivity of Striatum Based on the Integrated Connectivity Model in First-Episode Schizophrenia |
title_fullStr | Altered Functional Connectivity of Striatum Based on the Integrated Connectivity Model in First-Episode Schizophrenia |
title_full_unstemmed | Altered Functional Connectivity of Striatum Based on the Integrated Connectivity Model in First-Episode Schizophrenia |
title_short | Altered Functional Connectivity of Striatum Based on the Integrated Connectivity Model in First-Episode Schizophrenia |
title_sort | altered functional connectivity of striatum based on the integrated connectivity model in first-episode schizophrenia |
topic | Psychiatry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813199/ https://www.ncbi.nlm.nih.gov/pubmed/31681050 http://dx.doi.org/10.3389/fpsyt.2019.00756 |
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