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An uncharacterized region within the N-terminus of mouse TMC1 precludes trafficking to plasma membrane in a heterologous cell line

Mechanotransduction by hair cell stereocilia lies at the heart of sound detection in vertebrates. Considerable effort has been put forth to identify proteins that comprise the hair cell mechanotransduction apparatus. TMC1, a member of the transmembrane channel-like (TMC) family, was identified as a...

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Detalles Bibliográficos
Autores principales: Soler, D. C., Manikandan, M., Gopal, S. R., Sloan, A. E., McCormick, T. S., Stepanyan, R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813322/
https://www.ncbi.nlm.nih.gov/pubmed/31649296
http://dx.doi.org/10.1038/s41598-019-51336-0