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Fate-mapping post-hypoxic tumor cells reveals a ROS-resistant phenotype that promotes metastasis
Hypoxia is known to be detrimental in cancer and contributes to its development. In this work, we present an approach to fate-map hypoxic cells in vivo in order to determine their cellular response to physiological O(2) gradients as well as to quantify their contribution to metastatic spread. We dem...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813355/ https://www.ncbi.nlm.nih.gov/pubmed/31649238 http://dx.doi.org/10.1038/s41467-019-12412-1 |