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A nucleotide resolution map of Top2-linked DNA breaks in the yeast and human genome

DNA topoisomerases are required to resolve DNA topological stress. Despite this essential role, abortive topoisomerase activity generates aberrant protein-linked DNA breaks, jeopardising genome stability. Here, to understand the genomic distribution and mechanisms underpinning topoisomerase-induced...

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Detalles Bibliográficos
Autores principales:	Gittens, William H., Johnson, Dominic J., Allison, Rachal M., Cooper, Tim J., Thomas, Holly, Neale, Matthew J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813358/ https://www.ncbi.nlm.nih.gov/pubmed/31649282 http://dx.doi.org/10.1038/s41467-019-12802-5

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