ROS-mediated inactivation of the PI3K/AKT pathway is involved in the antigastric cancer effects of thioredoxin reductase-1 inhibitor chaetocin

Novel drugs are urgently needed for gastric cancer (GC) treatment. The thioredoxin-thioredoxin reductase (TRX-TRXR) system has been found to play a critical role in GC tumorigenesis and progression. Thus, agents that target the TRX-TRXR system may be highly efficacious as GC treatments. In this stud...

Descripción completa

Detalles Bibliográficos
Autores principales: Wen, Chuangyu, Wang, Huihui, Wu, Xiaobin, He, Lu, Zhou, Qian, Wang, Fang, Chen, Siyu, Huang, Lanlan, Chen, Junxiong, Wang, Huashe, Ye, Weibiao, Li, Wende, Yang, Xiangling, Liu, Huanliang, Peng, Junsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813365/
https://www.ncbi.nlm.nih.gov/pubmed/31649256
http://dx.doi.org/10.1038/s41419-019-2035-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813365/
https://www.ncbi.nlm.nih.gov/pubmed/31649256
http://dx.doi.org/10.1038/s41419-019-2035-x

Ejemplares similares