Aldolase‐Catalyzed Asymmetric Synthesis of N‐Heterocycles by Addition of Simple Aliphatic Nucleophiles to Aminoaldehydes

Nitrogen heterocycles are structural motifs found in many bioactive natural products and of utmost importance in pharmaceutical drug development. In this work, a stereoselective synthesis of functionalized N‐heterocycles was accomplished in two steps, comprising the biocatalytic aldol addition of et...

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Detalles Bibliográficos
Autores principales: Roldán, Raquel, Hernández, Karel, Joglar, Jesús, Bujons, Jordi, Parella, Teodor, Fessner, Wolf‐Dieter, Clapés, Pere
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Updates
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813633/
https://www.ncbi.nlm.nih.gov/pubmed/31680790
http://dx.doi.org/10.1002/adsc.201801530

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813633/
https://www.ncbi.nlm.nih.gov/pubmed/31680790
http://dx.doi.org/10.1002/adsc.201801530

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