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Synaptic localization of C9orf72 regulates post-synaptic glutamate receptor 1 levels

A hexanucleotide repeat expansion in a noncoding region of C9orf72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Reduction of select or total C9orf72 transcript and protein levels is observed in postmortem C9-ALS/FTD tissue, and loss of C9...

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Detalles Bibliográficos
Autores principales:	Xiao, Shangxi, McKeever, Paul M., Lau, Agnes, Robertson, Janice
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813971/ https://www.ncbi.nlm.nih.gov/pubmed/31651360 http://dx.doi.org/10.1186/s40478-019-0812-5

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