Systemic and local immunity following adoptive transfer of NY-ESO-1 SPEAR T cells in synovial sarcoma

BACKGROUND: Gene-modified autologous T cells expressing NY-ESO-1(c259), an affinity-enhanced T-cell receptor (TCR) reactive against the NY-ESO-1-specific HLA-A*02-restricted peptide SLLMWITQC (NY-ESO-1 SPEAR T-cells; GSK 794), have demonstrated clinical activity in patients with advanced synovial sa...

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Detalles Bibliográficos
Autores principales: Ramachandran, Indu, Lowther, Daniel E., Dryer-Minnerly, Rebecca, Wang, Ruoxi, Fayngerts, Svetlana, Nunez, Daniel, Betts, Gareth, Bath, Natalie, Tipping, Alex J., Melchiori, Luca, Navenot, Jean-Marc, Glod, John, Mackall, Crystal L., D’Angelo, Sandra P., Araujo, Dejka M., Chow, Warren A., Demetri, George D., Druta, Mihaela, Van Tine, Brian A., Grupp, Stephan A., Abdul Razak, Albiruni R., Wilky, Breelyn, Iyengar, Malini, Trivedi, Trupti, Winkle, Erin Van, Chagin, Karen, Amado, Rafael, Binder, Gwendolyn K., Basu, Samik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813983/
https://www.ncbi.nlm.nih.gov/pubmed/31651363
http://dx.doi.org/10.1186/s40425-019-0762-2

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