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Quality of life of patients on treatment for latent tuberculosis infection: a mixed-method study in Stockholm, Sweden
BACKGROUND: Unlike active tuberculosis, latent tuberculosis infection (LTBI) is asymptomatic and often considered not to affect the health-related quality of life (HRQoL) of patients. However, being diagnosed with and treated for LTBI can be associated with adverse clinical evens such side effects o...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813984/ https://www.ncbi.nlm.nih.gov/pubmed/31651339 http://dx.doi.org/10.1186/s12955-019-1228-4 |
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author | Shedrawy, Jad Jansson, Lena Röhl, Isac Kulane, Asli Bruchfeld, Judith Lönnroth, Knut |
author_facet | Shedrawy, Jad Jansson, Lena Röhl, Isac Kulane, Asli Bruchfeld, Judith Lönnroth, Knut |
author_sort | Shedrawy, Jad |
collection | PubMed |
description | BACKGROUND: Unlike active tuberculosis, latent tuberculosis infection (LTBI) is asymptomatic and often considered not to affect the health-related quality of life (HRQoL) of patients. However, being diagnosed with and treated for LTBI can be associated with adverse clinical evens such side effects of treatment as well as psychosocial challenges. Therefore, the aims of this study were to qualitatively explore patients’ experiences during diagnosis and treatment of LTBI in Stockholm measure their HRQoL, and contrast and merge the results to better understand how the HRQoL of these patients is affected. METHODS: LTBI patients who were treated in Stockholm during September 2017 and June 2018and who fulfilled the inclusion criteria were invited to fill a survey that included a HRQoL instrument, EQ-5D-3 L, and a mental health screening instrument, RHS-15. After filling the survey, a subset of these patients was asked to participate in an interview with open-ended questions that focused on their experiences during the diagnosis and treatment. RESULTS: In total 108 participants filled that survey and interviews were conducted with 20 patients. Patients scored relatively high on EQ-5D: the scores of utility and VAS scale are similar to those reported by the general population of Stockholm. Very few patients reported problems on the physical health domains of EQ-5D which was supported by the quantitative data that showed no effect on physical health and usual activity. Thirty-eight percent screened positive for RHS-15 and 27.8% reported problems with anxiety/depression domain of EQ-5D which could be related to many stressing factors mentioned in the interviews such as: fear and distress related to lack of clarity about LTBI diagnosis, perceived risk of infecting others and uncertainties about the future. CONCLUSION: The quantified HRQoL of LTBI patients in Stockholm is similar to the general population and there is thus no HRQoL decrements that is detectable with EQ-5D. However, the study reinforces the importance of tackling anxiety and fear and ensuring good health information for persons diagnosed with and treated for LTBI. |
format | Online Article Text |
id | pubmed-6813984 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-68139842019-10-30 Quality of life of patients on treatment for latent tuberculosis infection: a mixed-method study in Stockholm, Sweden Shedrawy, Jad Jansson, Lena Röhl, Isac Kulane, Asli Bruchfeld, Judith Lönnroth, Knut Health Qual Life Outcomes Research BACKGROUND: Unlike active tuberculosis, latent tuberculosis infection (LTBI) is asymptomatic and often considered not to affect the health-related quality of life (HRQoL) of patients. However, being diagnosed with and treated for LTBI can be associated with adverse clinical evens such side effects of treatment as well as psychosocial challenges. Therefore, the aims of this study were to qualitatively explore patients’ experiences during diagnosis and treatment of LTBI in Stockholm measure their HRQoL, and contrast and merge the results to better understand how the HRQoL of these patients is affected. METHODS: LTBI patients who were treated in Stockholm during September 2017 and June 2018and who fulfilled the inclusion criteria were invited to fill a survey that included a HRQoL instrument, EQ-5D-3 L, and a mental health screening instrument, RHS-15. After filling the survey, a subset of these patients was asked to participate in an interview with open-ended questions that focused on their experiences during the diagnosis and treatment. RESULTS: In total 108 participants filled that survey and interviews were conducted with 20 patients. Patients scored relatively high on EQ-5D: the scores of utility and VAS scale are similar to those reported by the general population of Stockholm. Very few patients reported problems on the physical health domains of EQ-5D which was supported by the quantitative data that showed no effect on physical health and usual activity. Thirty-eight percent screened positive for RHS-15 and 27.8% reported problems with anxiety/depression domain of EQ-5D which could be related to many stressing factors mentioned in the interviews such as: fear and distress related to lack of clarity about LTBI diagnosis, perceived risk of infecting others and uncertainties about the future. CONCLUSION: The quantified HRQoL of LTBI patients in Stockholm is similar to the general population and there is thus no HRQoL decrements that is detectable with EQ-5D. However, the study reinforces the importance of tackling anxiety and fear and ensuring good health information for persons diagnosed with and treated for LTBI. BioMed Central 2019-10-24 /pmc/articles/PMC6813984/ /pubmed/31651339 http://dx.doi.org/10.1186/s12955-019-1228-4 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Shedrawy, Jad Jansson, Lena Röhl, Isac Kulane, Asli Bruchfeld, Judith Lönnroth, Knut Quality of life of patients on treatment for latent tuberculosis infection: a mixed-method study in Stockholm, Sweden |
title | Quality of life of patients on treatment for latent tuberculosis infection: a mixed-method study in Stockholm, Sweden |
title_full | Quality of life of patients on treatment for latent tuberculosis infection: a mixed-method study in Stockholm, Sweden |
title_fullStr | Quality of life of patients on treatment for latent tuberculosis infection: a mixed-method study in Stockholm, Sweden |
title_full_unstemmed | Quality of life of patients on treatment for latent tuberculosis infection: a mixed-method study in Stockholm, Sweden |
title_short | Quality of life of patients on treatment for latent tuberculosis infection: a mixed-method study in Stockholm, Sweden |
title_sort | quality of life of patients on treatment for latent tuberculosis infection: a mixed-method study in stockholm, sweden |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813984/ https://www.ncbi.nlm.nih.gov/pubmed/31651339 http://dx.doi.org/10.1186/s12955-019-1228-4 |
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