The multi-site docking protein Grb2-associated binder 1 (Gab1) enhances interleukin-6-induced MAPK-pathway activation in an SHP2-, Grb2-, and time-dependent manner

BACKGROUND: Cytokine-dependent activation of signalling pathways is tightly orchestrated. The spatiotemporal activation of signalling pathways dictates the specific physiological responses to cytokines. Dysregulated signalling accounts for neoplastic, developmental, and inflammatory diseases. Grb2-a...

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Detalles Bibliográficos
Autores principales: Bongartz, Hannes, Gille, Karen, Hessenkemper, Wiebke, Mandel, Katharina, Lewitzky, Marc, Feller, Stephan M., Schaper, Fred
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814103/
https://www.ncbi.nlm.nih.gov/pubmed/31651330
http://dx.doi.org/10.1186/s12964-019-0451-2

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