Dissecting the dynamics of signaling events in the BMP, WNT, and NODAL cascade during self-organized fate patterning in human gastruloids

During gastrulation, the pluripotent epiblast self-organizes into the 3 germ layers—endoderm, mesoderm and ectoderm, which eventually form the entire embryo. Decades of research in the mouse embryo have revealed that a signaling cascade involving the Bone Morphogenic Protein (BMP), WNT, and NODAL pa...

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Detalles Bibliográficos
Autores principales: Chhabra, Sapna, Liu, Lizhong, Goh, Ryan, Kong, Xiangyu, Warmflash, Aryeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814242/
https://www.ncbi.nlm.nih.gov/pubmed/31613879
http://dx.doi.org/10.1371/journal.pbio.3000498

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814242/
https://www.ncbi.nlm.nih.gov/pubmed/31613879
http://dx.doi.org/10.1371/journal.pbio.3000498

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