Familial t(1;11) translocation is associated with disruption of white matter structural integrity and oligodendrocyte–myelin dysfunction

Although the underlying neurobiology of major mental illness (MMI) remains unknown, emerging evidence implicates a role for oligodendrocyte–myelin abnormalities. Here, we took advantage of a large family carrying a balanced t(1;11) translocation, which substantially increases risk of MMI, to underta...

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Detalles Bibliográficos
Autores principales: Vasistha, Navneet A., Johnstone, Mandy, Barton, Samantha K., Mayerl, Steffen E., Thangaraj Selvaraj, Bhuvaneish, Thomson, Pippa A., Dando, Owen, Grünewald, Ellen, Alloza, Clara, Bastin, Mark E., Livesey, Matthew R., Economides, Kyriakos, Magnani, Dario, Makedonopolou, Paraskevi, Burr, Karen, Story, David J., Blackwood, Douglas H. R., Wyllie, David J. A., McIntosh, Andrew M., Millar, J. Kirsty, ffrench-Constant, Charles, Hardingham, Giles E., Lawrie, Stephen M., Chandran, Siddharthan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814440/
https://www.ncbi.nlm.nih.gov/pubmed/31481758
http://dx.doi.org/10.1038/s41380-019-0505-2

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