CXCR5(+)CD8(+) T cells are a distinct functional subset with antitumor activity

CXCR5 mediates homing of both B and follicular helper T (T(FH)) cells into follicles of secondary lymphoid organs. We found that CXCR5(+)CD8(+) T cells are present in human tonsils and follicular lymphoma, inhibit T(FH)-mediated B-cell differentiation, and exhibit strong cytotoxic activity. Consiste...

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Detalles Bibliográficos
Autores principales: Chu, Fuliang, Li, Haiyan S., Liu, Xindong, Cao, Jingjing, Ma, Wencai, Ma, Ying, Weng, Jinsheng, Zhu, Zheng, Cheng, Xiaoyun, Wang, Zhiqiang, Liu, Jingwei, Jiang, Zi Yang, Luong, Amber, Peng, Weiyi, Wang, Jing, Balakrishnan, Kumudha, Yee, Cassian, Dong, Chen, Davis, Richard Eric, Watowich, Stephanie S., Neelapu, Sattva S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814517/
https://www.ncbi.nlm.nih.gov/pubmed/31028278
http://dx.doi.org/10.1038/s41375-019-0464-2

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