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AKT PHOSPHORYLATION OF MITOCHONDRIAL LonP1 PROTEASE ENABLES OXIDATIVE METABOLISM AND ADVANCED TUMOR TRAITS

Tumor mitochondria have heightened protein folding quality control, but the regulators of this process and how they impact cancer traits are not completely understood. Here we show that the ATP-directed mitochondrial protease, LonP1 is upregulated by stress conditions, including hypoxia, in tumor, b...

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Detalles Bibliográficos
Autores principales:	Ghosh, Jagadish C., Seo, Jae Ho, Agarwal, Ekta, Wang, Yuan, Kossenkov, Andrew V., Tang, Hsin-Yao, Speicher, David W., Altieri, Dario C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814529/ https://www.ncbi.nlm.nih.gov/pubmed/31406245 http://dx.doi.org/10.1038/s41388-019-0939-7

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