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Rapamycin for longevity: opinion article

From the dawn of civilization, humanity has dreamed of immortality. So why didn’t the discovery of the anti-aging properties of mTOR inhibitors change the world forever? I will discuss several reasons, including fear of the actual and fictional side effects of rapamycin, everolimus and other clinica...

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Autor principal: Blagosklonny, Mikhail V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814615/
https://www.ncbi.nlm.nih.gov/pubmed/31586989
http://dx.doi.org/10.18632/aging.102355
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author Blagosklonny, Mikhail V.
author_facet Blagosklonny, Mikhail V.
author_sort Blagosklonny, Mikhail V.
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description From the dawn of civilization, humanity has dreamed of immortality. So why didn’t the discovery of the anti-aging properties of mTOR inhibitors change the world forever? I will discuss several reasons, including fear of the actual and fictional side effects of rapamycin, everolimus and other clinically-approved drugs, arguing that no real side effects preclude their use as anti-aging drugs today. Furthermore, the alternative to the reversible (and avoidable) side effects of rapamycin/everolimus are the irreversible (and inevitable) effects of aging: cancer, stroke, infarction, blindness and premature death. I will also discuss why it is more dangerous not to use anti-aging drugs than to use them and how rapamycin-based drug combinations have already been implemented for potential life extension in humans. If you read this article from the very beginning to its end, you may realize that the time is now.
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spelling pubmed-68146152019-11-05 Rapamycin for longevity: opinion article Blagosklonny, Mikhail V. Aging (Albany NY) Research Perspective From the dawn of civilization, humanity has dreamed of immortality. So why didn’t the discovery of the anti-aging properties of mTOR inhibitors change the world forever? I will discuss several reasons, including fear of the actual and fictional side effects of rapamycin, everolimus and other clinically-approved drugs, arguing that no real side effects preclude their use as anti-aging drugs today. Furthermore, the alternative to the reversible (and avoidable) side effects of rapamycin/everolimus are the irreversible (and inevitable) effects of aging: cancer, stroke, infarction, blindness and premature death. I will also discuss why it is more dangerous not to use anti-aging drugs than to use them and how rapamycin-based drug combinations have already been implemented for potential life extension in humans. If you read this article from the very beginning to its end, you may realize that the time is now. Impact Journals 2019-10-04 /pmc/articles/PMC6814615/ /pubmed/31586989 http://dx.doi.org/10.18632/aging.102355 Text en Copyright © 2019 Blagosklonny. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Perspective
Blagosklonny, Mikhail V.
Rapamycin for longevity: opinion article
title Rapamycin for longevity: opinion article
title_full Rapamycin for longevity: opinion article
title_fullStr Rapamycin for longevity: opinion article
title_full_unstemmed Rapamycin for longevity: opinion article
title_short Rapamycin for longevity: opinion article
title_sort rapamycin for longevity: opinion article
topic Research Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814615/
https://www.ncbi.nlm.nih.gov/pubmed/31586989
http://dx.doi.org/10.18632/aging.102355
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